S100B蛋白在中枢神经系统疾病中的临床意义及研究进展

Clinical significance and progress of S100B protein in central nervous system diseases

S100钙结合蛋B(S100B)是主要由神经胶质细胞分泌的一种钙结合蛋白.它在各种体液(脑脊液,外周血和脐带血,尿液,唾液,羊水)中的含量被认为是多种疾病的生物标志物,尤其是在急性脑损伤、神经退行性疾病、先天性/围产期疾病等疾病中,而S100B的表达水平也是反馈疾病严重程度的重要标志.此外,S100B 蛋白不仅仅是一种生物学指标,也可作为疾病的治疗靶标.本文就S100B近几年来与中枢神经系统疾病的相关研究进展做一综述.

S100 calcium-binding protein B(S100B)is a calcium-binding protein secreted primarily by glial cells.Its content in various body fluids(cerebrospinal fluid,peripheral blood and umbilical cord blood,urine,saliva and amniotic fluid)is considered as a biomarker of various diseases,especially in acute brain injury,neurodegenerative diseases,congenital/perinatal diseases,etc.The expression level of S100B is also an important indicator of the severity of diseases.In addition,S100B is not only a biological indicator,but also a therapeutic target for diseases.In this paper,the research progress of S100B and central nervous system diseases in recent years is reviewed.