定志方治疗老年脑卒中后抑郁的效果及对认知功能、抑郁情绪与脑脊液蛋白水平的影响

Effect of Dingzhi Decoction on Post-stroke Depression in Elderly Patients and its Influence on Cognitive Function and Depression and Cerebrospinal Fluid Protein Level

目的:分析老年脑卒中后抑郁患者应用定志方治疗后疗效及认知功能、脑脊液蛋白水平变化。方法:采用随机数字表法将符合标准的117例老年脑卒中后抑郁患者分组,对照组58例给予常规西医治疗,观察组59例联合定志方煎服,对比2组患者治疗后认知功能、抑郁情绪、脑脊液蛋白水平及临床疗效。结果:治疗后,观察组总有效率、pAkt、P13K水平及MMES评分高于对照组,Bax、Bcl水平及HAMD评分低于对照组(P<0.05)。结论:定志方能够有效改善脑卒中后抑郁患者认知功能及抑郁情绪,其机制与介导P13K/Akt信号通路蛋白水平表达等有关。

Objective:To analyze the effects of Dingzhifang treatment on elderly patients with post-stroke depression,cognitive function,and changes in CSF protein levels.Methods:A random number table method was used to group 117 elderly patients with post-stroke depression who met the criteria.The control group was given conventional Western medicine treatment.The observation group was combined with Dingzhi decoction.The cognitive function,Depression,cerebrospinal fluid protein levels and clinical efficacy.Results:After treatment,the total effective rate,pAkt,P13K levels,and MMES scores in the observation group were higher than those in the control group,while Bax,Bcl levels,and HAMD scores were lower than those in the control group(P<0.05).Conclusion:Dingzhi decoction can effectively improve the cognitive function and depression of patients with post-stroke depression,and its mechanism is related to the expression of P13K/Akt signaling pathway protein levels.