地夸磷索钠联合玻璃酸钠滴眼液治疗干眼症的临床效果及安全性分析

Clinical effect and safety analysis of diquafosol sodium combined with sodium hyaluronate eye drops in the treatment of xerophthalmia

目的探究地夸磷索钠联合玻璃酸钠滴眼液治疗干眼症的临床效果及安全性。方法 80例干眼症患者,随机分为观察组及对照组,各40例。观察组给予地夸磷索钠联合玻璃酸钠滴眼液治疗,对照组给予玻璃酸钠滴眼液治疗。比较两组患者的治疗效果及不良反应发生情况。结果观察组患者的总有效率为97.50%,高于对照组的82.50%,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率为12.50%,与对照组的7.50%对比,差异无统计学意义(P>0.05)。结论地夸磷索钠联合玻璃酸钠滴眼液治疗干眼症,治疗效果较好,可有效的改善症状,且不良反应少,安全性高,此方法值得应用与推广。

Objective To investigate the clinical effect and safety of diquafosol sodium combined with sodium hyaluronate eye drops in the treatment of xerophthalmia. Methods A total of 80 xerophthalmia patients were randomly divided into observation group and control group, with 40 cases in each group. The observation group was treated by diquafosol sodium combined with sodium hyaluronate eye drops, and the control group was treated by sodium hyaluronate eye drops. The therapeutic effect and occurrence of adverse reactions between the two groups was compared. Results The total effective rate was 97.50% in the observation group, which was higher than 82.50% in the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions was 12.50% in the observation group, which had no statistically significant difference compared with 7.50% in the control group(P>0.05). Conclusion Diquafosol sodium combined with sodium hyaluronate eye drops shows good therapeutic effect in the treatment of xerophthalmia, and it can effectively improve the symptoms with less adverse reactions and high safety. It is worthy of application and promotion.