长链非编码RNA在神经胶质瘤分级的诊断价值分析

Analysis on the Diagnosic Value of Long Non-Coding RNA in the Disease Classifications of Patients With Neuroglioma

目的探究长链非编码RNA在神经胶质瘤中的表达及对疾病分级的检测价值。方法选取2017年10月—2019年6月期间的60例神经胶质瘤患者为观察组,同时期的30例颅脑损伤患者为对照组。比较两组的长链非编码RNA(XIST、ANRIL及DANCR)表达情况,同时比较观察组中不同分级患者的表达情况,并采用Pearson相关性分析上述指标与神经胶质瘤分级的关系。结果观察组的长链非编码RNA(XIST、ANRIL及DANCR)表达均高于对照组,且分级较高者的表达水平高于分级较低者,差异均有统计学意义(P<0.05),且Pearson相关性分析显示,上述指标与神经胶质瘤分级呈正相关(P<0.05)。结论长链非编码RNA在神经胶质瘤中的表达相对较高,且对疾病分级的检测价值较高。

Objective To investigate the expression of long non-coding RNA in neuroglioma and detection value for disease classifications.Methods 60 patients with neuroglioma from October 2017 to June 2019 were selected as the observation group,30 patients with craniocerebral trauma at the same time were selected as the control group.Then the expression situation of long non-coding RNA(XIST,ANRIL and DANCR)of two groups were compare,and the expression situation of observation group with different classifications were compared,then the relationship between those indexes and classifications of neuroglioma were analyzed with Pearson correlation analysis.Results The expression of long noncoding RNA(XIST,ANRIL and DANCR)of observation group were all higher than those of control group,the expression levels of patients with higher classifications were higher than those of patients with lower classifications,there were all statistically significant differences(P<0.05),the Pearson correlation analysis showed those indexes were positively correlated with classifications of neuroglioma(P<0.05).Conclusion The expression of long non-coding RNA in neuroglioma are relatively higher,and its detection value for disease classifications are higher.