孟鲁司特钠及西替利嗪治疗儿童咳嗽变异性哮喘的效果

Effect of Montelukast Sodium and Cetirizine on Cough Variant Asthma in Children

目的探究儿童咳嗽变异性哮喘给予孟鲁司特钠及西替利嗪的临床效果。方法选取2017年12月—2018年12月本院门诊收治的儿童咳嗽变异性哮喘患儿90例作为观察对象,按照随机数表法分为对照组(n=45)与观察组(n=45)。对照组行常规治疗,观察组实施孟鲁司特钠及西替利嗪联合治疗。比较两组患者咳嗽症状、疗效及复发率情况。结果经干预后,观察组日间、夜间咳嗽症状评分分别为(1.84±0.67)分、(1.56±0.46)分均低于对照组的(3.84±0.85)分、(2.25±0.37)分,组间差异有统计学意义(P<0.05)。观察组咳嗽缓解时间、咳嗽消失时间分别为(4.56±1.11)d、(6.23±1.87)d,均低于对照组的(6.56±1.03)d、(10.36±1.90)d,组间差异有统计学意义(P<0.05)。观察组临床总有疗效91.11%,明显高于对照组的71.11%,组间差异有统计学意义(P<0.05)。观察组复发率4.44%低于对照组复发率17.78%,组间差异有统计学意义(P<0.05)。结论为小儿咳嗽变异性哮喘患儿提供孟鲁司特钠及西替利嗪联合治疗,疗效显著,有效改善患儿临床症状,降低复发率,促使患者健康成长。

Objective To investigate the clinical application of montelukast sodium and cetirizine in children with cough variant asthma.Methods From December 2017 to December 2018,90 children with cough variant asthma admitted to our hospital were selected as the observation objects.According to the random number table method,they were divided into the control group(n=45)and the observation group(n=45).The control group was treated with routine therapy,and the observation group was treated with montelukast sodium and cetirizine.The cough symptoms,curative effect and recurrence rate of the two groups were compared.Results After intervention,the scores of daytime and nighttime cough symptoms in the observation group were(1.84±0.67)points and(1.56±0.46)points,respectively,which were lower than the control group(3.84±0.85)points and(2.25±0.37)points.The difference between the two shows statistical value(P<0.05).The cough remission time and cough disappearance time in the observation group were(4.56±1.11)d and(6.23±1.87)d,respectively,which were lower than the control group(6.56±1.03)d and(10.36±1.90)d.Academic value(P<0.05).The total clinical efficacy of the observation group was 91.11%,which was significantly higher than that of the control group(71.11%).The difference between the groups showed statistical value(P<0.05).The recurrence rate of the observation group was 4.44%lower than that of the control group 17.78%,and the difference between the groups was statistically significant(P<0.05).Conclusion The combination of montelukast sodium and cetirizine in children with cough variant asthma has significant curative effect,effectively improving the clinical symptoms of children,reducing the recurrence rate and promoting healthy growth of patients.