汉族人拉莫三嗪相关过敏反应与HLA-B*1502的相关性

Study on the correlation between HLA-B*1502 and lamotrigine-related allergic reactions in Han nationality

目的研究在汉族人中拉莫三嗪相关过敏反应是否与HLA-B*1502有相关性。方法对在郑州人民医院诊断为癫痫的患者在服用拉莫三嗪前进行HLA-B*1502测定,将服用拉莫三嗪12周后出现过敏反应者作为实验组,未出现过敏反应者作为对照组1,服用其他非芳香族抗癫痫药物出现过敏反应者为对照组2,检测对照组2的HLA-B*1502阳性率,对3组间HLA-B*1502的阳性率进行比较。结果实验组HLA-B*1502的阳性率为41.86%,对照组1为14.02%,对照组2为13.33%.实验组阳性率高于对照组1(χ2=13.86,P<0.05)及对照组2(χ2=6.83,P=0.009),对照组1与对照组2比较差异无统计学意义(χ2=0.009,P=0.924)。结论HLA-B*1502可能与汉族人拉莫三嗪相关过敏反应相关。

Objective To study the correlation between HLA-B*1502 and lamotrigine-related allergic reactions in Han nationality.Methods Patients diagnosed with epilepsy taking lamotrigine in Zhengzhou People's Hospital were selected as the study subjects.Patients who had allergic reactions after 12 weeks of taking lamotrigine were selected as the experimental group,and patients without allergic reactions were selected as the control group 1,at the same time,Those who had allergic reactions to other non-aromatic antiepileptic drugs were the control group 2.The positive rates of HLA-B*1502 in the three groups were tested,and the positive rates of HLA-B*1502 in the three groups were compared.Results The positive rate of HLA-B*1502 in the experimental group was 41.86%,and 14.02%in the control group one.and 13.33%in the control group two.The positive rate in the experimental group was higher than that in the control group one(χ2=13.86,P<0.05)and the control group two(χ2=6.83,P=0.009).The difference between control group 1 and control group 2 was not statistically significant(χ2=0.009,P=0.924).Conclusion HLA-B*1502 may be related to the allergic reaction of lamotrigine in Han nationality.