鼠神经生长因子联合丹红注射液治疗急性脑梗死认知功能障碍临床分析

Effect of mouse nerve growth factor and Danhong injection in cognitive dysfunction after acute cerebral infarction patients

目的评估鼠神经生长因子联合丹红注射液治疗急性脑梗死后认知功能障碍的临床疗效及安全性。方法选取在48 h内发病的脑梗死后认知功能障碍患者242例,随机分为对照组(121例)及治疗组(121例),治疗前后使用日常生活活动能力评定量表(ADL)及简易智能状态量表(MMSE)评估临床疗效,并对其安全性进行评价。结果2组患者治疗后日常生活活动能力评定及简易智能状态量表评分均较治疗前明显改善(P<0.05),且治疗组简易智能状态量表评分高于对照组(P<0.05)。治疗组总有效率(92.56%)高于对照组(75.21%)(P<0.05)。2组均未发生严重不良反应。结论鼠神经生长因子联合丹红注射液治疗急性脑梗死患者能有效改善卒中后认知功能障碍,且安全性较高。

Objective To evaluate the effectiveness and security of mouse nerve growth factor and Danhong injection in patients with cognitive dysfunction of acute cerebral infarction.Methods 242 patients with cognitive dysfunction after acute cerebral infarction were selected,onset time within 48 hours,which were randomly divided into two groups.The scores of ADL and MMSE were evaluated before and after treatment.The total effective rate in the treatment group(92.56%)was higher than that in the control group(75.21%)(P<0.05).No serious adverse reactions occurred in either group.Results The scores of ADL and MMSE were significantly higher than those before treatment.Conclusion Mouse nerve growth factor and Danhong injection can improve cognitive of acute cerebral infarction,and has high safety.