MHD患者cTnT与炎症因子水平变化及临床意义

Changes and clinical significance of cTnT and inflammatory factors in patients undergoing MHD

目的探究维持性血液透析(MHD)患者cTnT与炎症因子水平变化及预后的预测价值。方法回顾性分析2016年3月至2017年3月本院收治的96例MHD患者临床资料,治疗后随访2年,判断患者预后情况,比较不同预后患者cTnT、IL-6、CRP水平,分析cTnT、IL-6、CRP三者的相关性。结果所有患者随访期间有44例出现不良心血管事件;MHD预后不良患者血清中cTnT、IL-6、CRP水平高于预后良好患者,差异有统计学意义(P<0.05);cTnT与IL-6、CRP之间呈正相关(r=0.435,0.513;P<0.05),IL-6与CRP之间关系也呈正相关(r=0.387,P<0.05)。结论维持性血液透析患者cTnT、IL-6、CRP水平上升,提示患者预后不良,作为预测患者预后临床指标。

Objective To investigate the changes of cTnT and inflammatory factors in patients undergoing maintenance hemodialysis(MHD)and predictive value for prognosis.Methods The clinical data of 96 patients undergoing MHD in the hospital from March 2016 to March 2017 were analyzed retrospectively.The patients were followed up for 2 years after treatment,and the prognosis was determined.The levels of cTnT,IL-6 and CRP were compared between patients with different prognosis.The correlations among cTnT,IL-6 and CRP were analyzed.Results There were 44 cases with adverse cardiovascular events during follow-up period.The levels of cTnT,IL-6 and CRP in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).CTnT was positively correlated with IL-6 and CRP(r=0.435,0.513;P<0.05),and IL-6 was positively correlated with CRP(r=0.387,P<0.05).Conclusion The levels of cTnT,IL-6 and CRP increase in patients undergoing MHD,indicating poor prognosis.They can be used as clinical indexes to predict patients'prognosis.