电针对脓毒症心肌损伤病人microRNA-133a表达影响

Effect of electroacupuncture on the expression level of microRNA-133a in sepsis patients complicated with myocardial injury

目的:探讨电针对脓毒症心肌损伤病人microRNA-133a表达影响。方法:60例脓毒症心肌损伤病人随机分为对照组与电针组,各30例,对照组给予西医常规治疗,电针组在西医常规治疗基础上加用电针,疗程7 d。比较2组治疗前后microRNA-133a、急性生理学及慢性健康状况(APACHEⅡ)评分、肌钙蛋白(cTnT)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、含半胱氨酸的天冬氨酸蛋白水解酶3(caspase-3)、B淋巴细胞瘤-2基因(Bcl-2)、左心室射血分数(LVEF)。结果:治疗后2组病人microRNA-133a、APACHEⅡ评分、cTnT、IL-6、TNF-α、caspase-3、Bcl-2、LVEF均明显改变,电针组明显优于对照组(P<0.01);microRNA-133a与APACHEⅡ评分、cTnT、IL-6、TNF-α、Bcl-2存在线性关系。结论:电针对于脓毒症心肌损伤有效,microRNA-133a可以作为诊断脓毒症心肌损伤的指标之一。

Objective:To observe the effects of electroacupuncture on the expression level of microRNA-133a in sepsis patients complicated with myocardial injury.Methods:Sixty sepsis patients complicated with myocardial injury were randomly divided into the electroacupuncture group and control group(30 cases in each group).Two groups were treated with routine method,and the electroacupuncture group were additionally treated with electroacupuncture for 7 d.The expression level of microRNA-133a,APACHEⅡscore,and levels of caspase-3,Bcl-2,TNF-α,IL-6,cTnT and LVEF in two groups were compared between before and after treatment.Results:After treatment,the obvious changes of the APACHEⅡscore,levels of microRNA-133a,caspase-3,Bcl-2,TNF-α,IL-6,cTnT and LVEF were found in two groups,and those in electroacupuncture group were significantly better than those in control group(P<0.01).There were the linear relationships between microRNA-133a,and APACHEⅡscore,caspase-3,Bcl-2,TNF-α,IL-6 and cTnT.Conclusions:The effect of electroacupuncture in treating sepsis patients complicated with myocardial injury is good,and microRNA-133a can be used as an indicator in diagnosing sepsis complicated with myocardial injury.