他克莫司治疗特应性皮炎的效果及对患者免疫功能的影响

Effect of tacrolimus ointment on atopic dermatitis and skin barrier function

目的探讨他克莫司治疗特应性皮炎的临床效果及对患者免疫功能的影响。方法选取辽宁省某医院2016年12月-2019年3月收治的120例特应性皮炎患者为研究对象,采用随机数字表法分为对照组和观察组,每组60例。对照组患者给予盐酸左西替利嗪口服液治疗,观察组患者在对照组基础上给予0.03%他克莫司软膏治疗,比较2组患者临床疗效、不良反应发生情况,治疗前后T淋巴细胞亚群中CD4+、CD8+,自然杀伤(NK)细胞水平及CD4+/CD8+水平。结果治疗前,2组患者血清CD4+,CD8+,NK细胞水平及CD4+/CD8+水平比较,差异无统计学意义(P>0.05);治疗后,2组患者血清CD4+,CD4+/CD8+水平均高于治疗前,NK细胞水平低于治疗前,且观察组患者CD4+细胞水平及CD4+/CD8+水平均高于对照组,NK细胞水平低于对照组,差异均有统计学意义(P<0.05)。观察组患者治疗总有效率为96.67%(58/60),高于对照组的83.33%(50/60),差异有统计学意义(P<0.05)。2组患者治疗期间均无明显不良反应发生,差异无统计学意义(P>0.05)。结论他克莫司治疗特应性皮炎效果较好,可有效改善患者免疫功能,安全性较好,值得推广。

Objective To explore the effect of tacrolimus ointment on the clinical efficacy and immune function of atopic dermatitis.Methods One hundred and twenty patients with atopic dermatitis admitted to a hospital in Liaoning from December 2016 to March 2019 were selected.Random number method was used to divide them into control group and observation group,60 cases each.The control group was treated with levocetirizine hydrochloride oral solution,while the observation group was treated with 0.03%tacrolimus ointment on the basis of the control group.The changes of T lymphocyte subsets(CD4+,CD8+,NK)and NK CD4+/CD8+before and after treatment were compared between the two groups.Results Before treatment,there was no significant difference in CD4+cell,CD8+cell NK cell levels,CD4+/CD8+,between the two groups(P>0.05);after treatment,the levels of CD4+cell,CD4+/CD8+in the two groups increased significantly,and the levels of NK cells decreased(P<0.05);after treatment,the levels of CD4+cell,CD4+/CD8+in the observation group were higher than those in the control group,and the levels of NK cells were lower than those in the control group(P<0.05).The total effective rate of the observation group was 96.67%(58/60),which was significantly higher than that of the control group[(83.33%(50/60),P<0.05)].During the treatment,there was no significant adverse reaction between the two groups(P>0.05).Conclusion Tacrolimus ointment can effectively improve the immune function of atopic dermatitis patients.It has significant clinical effect and is safe to use.It is worthy of application and promotion.