北京某医院消化内科肝炎病毒感染的流行病学调查

Prevalence of Hepatitis Viruses in the Department of Gastroenterology in a Hospital of Beijing

目的了解肝炎病毒在中国人民解放军总医院第五医学中心消化内科的流行情况,为临床治疗提供参考。方法选取2012年1月至2017年12月我中心消化内科因各种肝脏疾病而入院的患者为研究对象,共228例,同时进行肝炎病毒核酸和抗原抗体检测。结果在228例患者中,HBsAg阳性患者占12.72%(29/228),anti-HCV阳性患者占2.63%(6/228),HEV RNA阳性患者占0.88%(2/228),HGV RNA阳性患者占0.44%(1/228),未检测到HAV和HDV感染患者。HBV/HEV混合感染1例,其余均为单独感染。对89.66%(26/29)的HBsAg阳性患者进行核酸检测,其中84.62%(22/26)为HBV DNA阳性,病毒载量的中位值为5.50×105(IQR,1.00×103~1.89×106)IU/mL。对66.67%(4/6)的anti-HCV阳性患者进行核酸检测,仅有1例HCV RNA阳性,病毒载量为2.56×106 IU/mL。结论我中心消化内科肝炎病毒主要为HBV,其次为HCV,HEV和HGV感染率均较低,未发现HAV和HDV感染者。

Objective To investigate the prevalence of hepatitis viruses in the Department of Gastroenterology in the 5th medical center of the PLA general hospital and to provide a reference for the clinical treatment.Methods 228 patients,who were admitted to the Department of Gastroenterology of our hospital due to various liver diseases,were enrolled in the study from January,2012 to December,2017.All patients were tested for the presence of DNA/RNA,antigens,and antibodies of hepatitis viruses.Results Among 228 patients,12.72%(29/228),2.63%(6/228),0.88%(2/228),and 0.44%(1/228)were HBsAg positive,anti-HCV positive,HEV RNA positive,and HGV RNA positive,respectively.No HAV and HDV infections were detected in these patients.Mixed infections were only found in 1 patient(HBV/HEV).Among 89.66%(26/29)of HBsAg-positive patients,84.62%(22/26)were HBV DNA positive and the corresponding median viral load was 5.50×105IU/mL(IQR,1.00×103-1.89×106).Among 66.67%(4/6)of anti-HCV-positive patients,only 1 patient was HCV RNA positive and the corresponding viral load was 2.56×106 IU/mL.Conclusion The dominant hepatitis viruses in the Department of Gastroenterology of our hospital are mainly HBV,followed by HCV.HEV and HGV infections are rarely detected.No HAV and HDV infections are detected in the current study.