血清纤维蛋白原水平及白蛋白/球蛋白比值与直肠癌患者生存预后的关系

The Relationship Between Serum Fibrinogen Level and Albumin/Globulin Ratio and Survival Prognosis in Patients with Rectal Cancer

目的探讨血清纤维蛋白原水平及白蛋白/球蛋白比值对直肠癌患者生存预后的影响。方法选取我科2010年1月至2013年1月收治的直肠癌患者120例,检测术前患者的血清FIB、AGR水平,根据血清FIB、AGR水平,分为FIB正常组(48例)和FIB高水平组(72例)、AGR正常组(45例)和AGR低水平组(75例);分析术前血清FIB、AGR与直肠癌患者的临床病理学特征关系,判断血清FIB、AGR对直肠癌患者生存预后的影响。结果患者检测术前血清FIB高水平组值6.53±1.28 g/L高于FIB正常组3.12±0.61 g/L,差异具有统计学意义(P<0.05);血清AGR低水平组值1.23±0.08低于AGR正常组值2.12±0.19,差异具有统计学意义(P<0.05)。血清FIB、AGR水平与直肠癌患者的BMI、肿瘤直径、TNM分期和淋巴结转移有关(P<0.05)。单因素分析显示:肿瘤直径>2cm、TNMⅢ期、淋巴结转移、FIB升高和AGR降低是影响直肠癌患者的危险因素(P<0.05);多因素分析显示:淋巴结转移、FIB升高和AGR降低是影响直肠癌患者生存预后的独立危险因素(P<0.05)。结论血清FIB、AGR值正常患者生存预后优于血清FIB升高、AGR降低患者;血清FIB水平升高、AGR水平降低可作为影响直肠癌患者生存率的的独立危险因素。

Objective To investigate the effect of serum fibrinogen level and albumin/globulin ratio on survival and prognosis of patients with rectal cancer.Methods A total of 120 patients with rectal cancer admitted to our department from January,2010 to January,2013 were enrolled for the study.The serum FIB and AGR levels of preoperative patients were measured.According to serum FIB and AGR levels,they were divided into the FIB normal group(48 cases)and the FIB high level group(72 cases),as well as the AGR normal group(45 cases)and the AGR low level group(75 cases).The relationships between serum FIB,AGR levels and clinicopathological features of patients with rectal cancer were analyzed,so to determine the effect of serum FIB and AGR on the survival prognosis of patients with rectal cancer.Results The value of preoperative serum FIB high level group(6.53±1.28)was higher than the FIB normal group(3.12±0.61)(P<0.05);the value of serum AGR low level group(1.23±0.08)was lower the normal group(2.12±0.19)(P<0.05).Serum FIB and AGR levels were associated with BMI,tumor diameter,TNM stage and lymph node metastasis in patients with rectal cancer(P<0.05).Univariate analysis showed that tumor diameter greater than 2cm,TNM stage III,lymph node metastasis,elevated FIB and decreased AGR were risk factors for patients with rectal cancer(P<0.05).Multivariate analysis showed lymph node metastasis,FIB elevation and AGR decrease were independent risk factor for survival prognosis in patients with rectal cancer(P<0.05).Conclusion Patients with normal serum FIB and AGR values have a better survival prognosis than patients with elevated serum FIB and decreased AGR.Serum FIB levels and decrease of AGR levels might be independent risk factors for survival of rectal cancer patients.