基于数据挖掘技术分析针灸治疗脊髓损伤后神经源性膀胱的取穴规律

The rules of acupoint selection in the treatment of neurogenic bladder after spinal cord injury with acupuncture and moxibustion:based on data mining technology

背景:目前,许多的研究表明针灸治疗脊髓损伤后神经源性膀胱具有显著疗效,但对于此病的治疗尚无统一的针灸处方标准。目的:探究针灸治疗脊髓损伤后神经源性膀胱的取穴规律。方法:检索1989年至2020年1月发表于中国知网、万方数据资源系统、维普数据库和中国生物医学文献数据库中的有关针灸治疗脊髓损伤后神经源性膀胱的相关临床文献,建立数据库对所收集文献的针灸处方进行描述性分析、关联规则分析和聚类分析。结果与结论:(1)共计纳入文献93篇,经数据汇总、分析显示针灸治疗脊髓损伤后的神经源性膀胱使用频率最高的腧穴和经络分别为中极(CV3)(频次55)、足太阳膀胱经(频次161);(2)关联规则分析显示支持度最高的穴位组合为关元(CV4)-中极(CV3);(3)将使用频率≥10的腧穴进行聚类分析,结果显示腧穴可分为2类;(4)上述数据证实,针灸治疗脊髓损伤后神经源性膀胱时选穴多为循经选穴和局部选穴,临床治疗可利用数据挖掘得出的关联规则分析和聚类分析结果合理取穴配穴并重用特定穴以提高治病效果。

BACKGROUND:Increasing studies have shown that acupuncture has a significant effect on the treatment of neurogenic bladder after spinal cord injury,but there is no uniform acupuncture prescription standard for the treatment of this disease.OBJECTIVE:To investigate the rules of selecting acupoints in the treatment of neurogenic bladder after spinal cord injury with acupuncture and moxibustion.METHODS:Clinical literatures related to acupuncture treatment of neurogenic bladder after spinal cord injury were retrieved in China Knowledge Network,WanFang Data,VIP database and China Biology Medicine disc from 1989 to January 2020.Then,we established a database to perform descriptive analysis,relevance principle analysis and cluster analysis of the collected acupuncture prescriptions.RESULTS AND CONCLUSION:A total of 93 articles were included.Data collection and analysis showed that the acupoints and meridians with the highest frequency of neurogenic bladder after acupuncture treatment of spinal cord injury were Zhongji(CV3)(with the frequency of 55)and Bladder Meridian of Foot Taiyang(with the frequency of 161).Relevance principle analysis showed that combination of acupoints with strongest support is Guanyuan(CV4)and Zhongji(CV3).Cluster analysis of acupoints with the frequency≥10 showed that acupoints could be divided into two categories.All these findings indicate that when acupuncture and moxibustion is used to treat neurogenic bladder after spinal cord injury,most of the acupoints along the meridians and local acupoints are selected.The results of relevance principle analysis and cluster analysis obtained from data mining can be used to select acupoints,match acupoints and reuse specific acupoints to improve the therapeutic efficacy.