止咳定喘汤联合孟鲁司特在咳嗽变异性哮喘中的临床疗效

Clinical Efficacy of Zhike Dingchuan Decoction Combined with Montelukast in Cough Variant Asthma

目的探讨止咳定喘汤联合孟鲁司特对咳嗽变异性哮喘患者炎症因子及气道反应性的影响,分析其临床疗效。方法咳嗽变异性哮喘患者120例,按随机数字表法将患者分为孟鲁司特钠咀嚼片治疗组40例,单独止咳定喘汤治疗组40例,止咳定喘汤联合孟鲁司特治疗组40例,连续治疗3个月,观察各组患者血清的白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、血清IgE水平、肺功能指标、呼气一氧化氮(FeNO)、ACT评分和AQLQ评分变化。结果治疗后止咳定喘汤联合孟鲁司特治疗组的血清IL-1β、IL-6、TNF-α、IgE水平明显低于单独止咳定喘汤组和单独使用孟鲁司特组患者(P<0.05);止咳定喘汤联合孟鲁司特治疗组的肺功能指标FEV1、FEV1/FVC、FEV1%,FEV1改善率、FeNO、ACT评分、AQLQ评分明显优于单独止咳定喘汤组和单独使用孟鲁司特组患者(P<0.05)。结论止咳定喘汤联合孟鲁司特治疗咳嗽变异性哮喘可以有效缓解患者的炎症反应,增强免疫力,改善患者的肺功能,控制患者的哮喘,具有极大的临床应用价值。

Objective To investigate the effect of Zhike Dingchuan decoction combined with montelukast on inflammatory factors and airway responsiveness in patients with cough variant asthma,and to analyze its clinical efficacy.Methods 120 patients who met the CVA diagnostic criteria were selected as the research objects.And according to the random number table method,the patients were divided into experimental group who was treated with Zhike Dingchuan decoction combined with montelukast(n=40),control group 1 who was treated with montelukast sodium chewable tablet(n=40),and control group 2 who was treated with Zhike Dingchuan decoction(n=40).The treatments continued for 3 months and the serum IL-1β,IL-6,TNF-α,serum IgE levels,pulmonary function,FeNO,ACT,and AQLQ were monitored and compared.Results The serum levels of IL-1β,IL-6,TNF-α,and IgE in the experimental group were significantly lower than those in the treatment group of Zhike dingchuan decoction alone and montelukast alone(P<0.05),and the pulmonary function indexes FEV1,FEV1/FVC,FEV1%,FEV1 improvement rate,FeNO,ACT score,AQLQ score were significantly better in the experimental group than those in the control group 1 and 2,and the differences were statistically significant(P<0.05).Conclusion The treatment of cough variant asthma with Zhike Ding chuan decoction combined with montelukast could effectively relieve the inflammatory response,enhance the immunity,improve the lung function of the patients,and control the patient's asthma,which have great clinical application values.