JAK2-STAT3信号通路介导骨关节炎发病机制的研究进展

Research Progress of Pathogenesis of JAK2-STAT3 Signaling Pathway Mediating Osteoarthritis

骨关节炎是一种以骨关节肿痛、畸形伴活动受限的慢性进行性、退变性疾病,发病机制较复杂,目前尚未完全阐明。JAK激酶(JAK)-信号转导及转录激活因子(STAT)信号通路可广泛参与机体的生物学过程,主要通过细胞因子介导发挥相应的生物学效应,对调节细胞增殖、分化、凋亡及炎症反应起重要作用。JAK2-STAT3信号通路与骨关节炎发病机制密切相关,通过检测骨关节炎患者关节液、滑膜及关节软骨中相关蛋白的表达水平可明确其与骨关节炎的相关性,对骨关节炎发病机制中JAK2-STAT3信号转导通路作用的研究将为骨关节炎的治疗提供新的思路。

Osteoarthritis is a kind of chronic progressive and degenerative disease,which is characterized by swelling and pain of bone and joint,and deformity with limited activity.The pathogenesis of osteoarthritis is complex and has not been fully elucidated.Janus kinase(JAK)-signal transduction and activator of transcription(STAT)signaling pathway is widely involved in the biological process of the body,which plays an important role in regulating cell proliferation,differentiation,apoptosis and inflammatory response,mainly through cytokine mediation.JAK2-STAT3 signaling pathway is closely related to the pathogenesis of osteoarthritis.By detecting the expression level of related proteins in the joint fluid,synovium and articular cartilage of the patients,the correlation between JAK2-STAT3 signaling pathway and osteoarthritis can be determined.The research on the role of JAK2-STAT3 signaling pathway in the pathogenesis of osteoarthritis will provide new ideas for the treatment.