摘要
中性粒细胞与淋巴细胞比值(NLR)是一种较为敏感的炎症反应指标。肿瘤的发生、进展过程往往伴随炎症反应的发生。妇科恶性肿瘤(如宫颈癌、卵巢癌)可用NLR进行预测诊断,但NLR对于内膜癌的诊断尚需进一步研究。此外,NLR值的高低可以反映妇科恶性肿瘤的预后情况,同时对于辅助放化疗患者的预后也有一定意义。但NLR值在妇科恶性肿瘤中的诊断及预后最佳截断值的获取还有待进一步研究,且NLR值对于疾病的特异性及敏感性报道各异,因此NLR不能在临床实践中作为单一的生物标志物。但NLR作为一种生物标志物有望引进未来的预测模型中,将提高对妇科恶性肿瘤的诊断率及预后评估。
Neutrophil to lymphocyte ratio(NLR)is a sensitive indicator of inflammatory response.The occurrence and progression of tumors are often accompanied by inflammatory reactions.NLR can be used for prediction and diagnosis of gynecologic malignancies such as cervical and ovarian cancer,but further research is needed on the diagnosis of endometrial cancer.In addition,the NLR value can reflect the prognosis of gynecologic malignant tumors,and also has certain significance for the prognosis of patients receiving adjuvant chemoradiotherapy.However,the optimal cut-off value of NLR for the diagnosis and prognosis in gynecologic malignant tumors remains to be further studied,and the reports on specificity and sensitivity of NLR to diseases vary,so NLR cannot be used as a single biomarker in clinical practice.However,as a biomarker,NLR is expected to be introduced into future prediction models,which will improve the diagnosis rate and prognosis evaluation of gynecologic malignancies.
作者
王燕萍
吴素慧
WANG Yanping;WU Suhui(Shanxi Medical University,Taiyuan 030000,China;Department of Obstetrics and Gynecology,Shanxi Bethune Hospital,Taiyuan 030000,China)
出处
《医学综述》
2020年第7期1304-1308,1313,共6页
Medical Recapitulate
