氟比洛芬酯的合成进展

Progress in the Synthesis of Flurbiprofen

氟比洛芬酯作为一种新型非甾体的靶向镇痛药,通过抑制环氧化酶减少前列腺素的合成,降低手术创伤引起的痛觉过敏状态。由于其酯微球制剂药效更强,起效更迅速,持续时间更长,且不易引起胃黏膜损伤等不良反应,其用于术后镇痛或因癌症引起的疼痛在临床得到广泛应用。因此通过简洁高效的方法来合成氟比洛芬酯成为当前的热点研究课题。本文总结了国内外近年在氟比洛芬酯的合成方法领域取得的研究成果。

Flurbiprofen axetil is a new nonsteroidal targeted analgesic. It can reduce the synthesis of prostaglandins by inhibiting cyclooxygenase and reduce the hyperalgesia caused by surgical trauma. The ester microsphere preparation is more effective, has a faster onset, lasts longer, and is less likely to cause adverse reactions such as gastric mucosal damage. It is widely used clinically for postoperative analgesia or pain caused by cancer. Therefore, the synthesis of flurbiprofen ester by a simple and efficient method has become a hot research topic. This article summarizes the research results obtained in the field of synthesis methods of flurbiprofen ester at home and abroad in recent years.