帕金森病的治疗进展

Progress in Treatment of Parkinson’s Disease

帕金森病(PD)是中枢神经系统常见的进行性疾病。PD脑黑质和黑质纹状体通路病变是脑黑质致密部的多巴胺能神经元缺失所致。PD的主要特点是肌肉僵硬、运动迟缓和静止性震颤,影响患者的生活质量,严重威胁患者的生命。左旋多巴是治疗PD的主要药物,不良反应明显,长期服用疗效会逐渐降低。通过对PD治疗及中医辨证防治的研究发现,中药在保护神经细胞、抑制氧化应激反应等方面取得了一定的进展,为PD的治疗提供了新的参考依据。

Parkinson’s disease(PD)is a common progressive disease of the central nervous system.The brain substantia nigra and nigrostriatal pathway pathological changes of PD are caused by the loss of dopamine neurons in the dense substantia nigra of the brain.The main features of PD are muscle stiffness,bradykinesia,and resting tremor,seriously threatening the life and quality of life of the patients.Levodopa is still the main drug for the treatment of PD,but the adverse effects are obvious,and long-term use will gradually reduce the efficacy.Studies on the status of PD treatment and dialectical prevention and treatment of TCM found that Chinese medicine has made some progress in protecting nerve cells and inhibiting oxidative stress,which provides a new reference for the treatment of PD.