丁苯酞注射液联合尤瑞克林治疗急性缺血性卒中的临床疗效及安全性评价

Evaluation on clinical curative effects and safety of butylphthalide injection combined with urinary kallidinogenase in treatment of acute ischemic stroke

目的 探讨丁苯注射液联合尤瑞克林治疗急性缺血性卒中的临床疗效及安全性.方法 选取本院2018年3月~2019年3月接收的急性缺血性卒中患者90例,根据随机数字表法分组,对照组45例实施常规治疗,研究组45例基于此实施丁苯注射液联合尤瑞克林治疗,比较两组临床疗效及安全性.结果 治疗后,研究组患者hs-CRP、R、Zc均明显低于对照组,Q、V、NIHSS评分、治疗有效率均明显高于对照组,而BA、RVA、LVA的Vm也明显高于对照组,BA、RVA、LVA的PI也明显低于对照组,差异有统计学意义(P<0.05),两组不良反应发生率比较,差异无统计学意义(P>0.05).结论 丁苯注射液联合尤瑞克林治疗急性缺血性卒中的临床疗效较显著,能明显改善患者脑部血流动力学及炎症,可维持血管正常血流,有助于提高神经功能.

Objective To explore the clinical curative effects and safety of butylphthalide injection combined with urinary kallidinogenase in treatment of acute ischemic stroke.Methods Ninety patients with acute ischemic stroke who were admitted to our hospital from March 2018 to March 2019 were selected.They were divided into two groups according to the random number table method.45 patients in the control group were given routine therapy while 45 patients in the study group were treated with butylphthalide injection combined with urinary kallidinogenase based on this.The clinical curative effects and safety of the two groups were compared.Results After treatment,the hs-CRP,R and Zc of the study group were significantly lower than those of the control group while Q,V,NIHSS scores and effective rate of treatment were significantly higher than those of the control group.Vm of BA,RVA and LVA were also significantly higher than those of the control group.PI of BA,RVA and LVA were also significantly lower than those of the control group.Differences between groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butene injection combined with urinary kallidinogenase in treatment of acute ischemic stroke has significant curative effects.It can significantly improve the cerebral hemodynamics and inflammation and maintain the normal blood flow of blood vessels,which contributes to the improvement of neurological function.