不含卤素的激素经鼻雾化在分泌性中耳炎患者中的效果与安全性研究

Study on the effect and safety of halogen-free hormone in patients with secretory otitis media by nasal atomization

目的 探讨不含卤素的激素经鼻雾化在分泌性中耳炎患者中的效果与安全性.方法 选取2017年2月~2019年2月在我院接受治疗的分泌性中耳炎的患者128例(156耳),采用随机数字表法将患者分成对照组和实验组;对照组采用常规口服抗生素联合曲安奈德鼻喷雾剂进行治疗,实验组采用无稀释普米克令舒进行治疗,坚持治疗2周;观察比较两组患者的疗效、纯听阀测定水平数据及不良反应数据.?结果?实验组的总有效率为92.19%,对照组的总有效率为81.25%,实验组的疗效明显优于对照组,差异有统计学意义(P<0.05);实验组患者的纯听阀测定水平数据均高于对照组,差异有统计学意义(P<0.05);两组患儿在治疗的过程中均未出现严重的并发症,实验组患者的总不良反应发生率为4.69%;对照组患者的总不良反应发生率为6.25%,两组患者的不良反应数据比较差异无统计学意义(P>0.05).结论 ?不含卤素的激素经鼻雾化在分泌性中耳炎患者中的疗效较好,安全性较高,值得临床推广.

Objective To investigate the effect and safety of halogen-free hormone in patients with secretory otitis media by nasal atomization.Methods 128 patients(156 ears)with secretory otitis media who were treated at our hospital from February 2017 to February 2019 were selected,and randomly divided into the control group and the experimental group by random number table method;the control group was treated with conventional oral antibiotics combined with triamcinolone acetonide nasal spray,while the experimental group was treated with undiluted Pulmicort respules,and the treatment was maintained for 2 weeks;the efficacy,data of pure hearing threshold determination level,and data of adverse reactions in the two groups of patients were observed and analyzed.Results The overall response rate in the experimental group was 92.19%,while that in the control group was 81.25%;the efficacy in the experimental group was significantly better than that in the control group,and the difference in data was statistically significant(P<0.05);the data of pure hearing threshold determination level of patients in the experimental group were all higher than those in the control group,and the difference in data was statistically significant(P<0.05);no serious complications occurred during the treatment in either group of patients;the overall incidence of adverse reactions in patients was 4.69%in the experimental group and 6.25%in the control group;there was no statistically significant difference in the data of adverse reactions between the two groups of patients(P>0.05).Conclusion Halogen-free hormone has a better efficacy in patients with secretory otitis media by nasal atomization,with higher safety,which is worthy of clinical promotion.