介孔碳球的制备及作为药物传输系统的应用

Mesoporous Carbon Spheres:Synthesis and Applications in Drug Delivery System

介孔碳球是一种新型多孔球形碳材料,因具有比表面积大、化学稳定性高、生物相容性好以及孔容孔径可调及粒径大小可控等许多优点,在生物医药、能量储存与转化、环境治理和催化等领域有着巨大的应用前景。本文介绍了模板法、Stober法和微流控液滴法制备介孔碳球的相关研究,综述了近年来介孔碳球作为药物传输系统(Drug delivery system,DDS)的应用研究进展,重点对表面性质控释、刺激响应控释、靶向输送、诊疗一体化等四种DDS的研究进行了评述,并提出了当前介孔碳球制备及在作为癌症治疗DDS的应用中尚待解决的主要问题和发展趋势。

Mesoporous carbon spheres are a new type of porous spherical carbon materials.They are promising in many fields such as biomedicine,energy storage/conversion,environmental treatment,and catalysis,thanks to their high surface area,good chemical stability,excellent biocompatibility,tunable pore sizes and volume,and controllable particle size distribution.In the present work,recent advances in the preparing methods of mesoporous carbon spheres,including templating methods,St ber methods,and microfluidic droplets methods,are summarized.Moreover,the applications of mesoporous carbon spheres as drug delivery system(DDS)including controlled surface property release,stimuli-responsive release,targeted delivery,and theranostic delivery,are reviewed.Finally,the main problems and development trends in the synthesis of mesoporous carbon spheres and applications in DDS for cancer therapy are proposed and discussed.