氟尿嘧啶联合放疗对原发性肝癌患者治疗效果及对血清LPO、MDA水平的影响

The therapeutic effect of fluorouracil combined with radiotherapy on patients with primary liver cancer and its effect on serum LPO and MDA levels

目的探究氟尿嘧啶联合放疗对原发性肝癌患者的治疗效果及对血清过氧化脂(LPO)、丙二醛(MDA)水平的影响。方法选取2016年3月至2017年3月于恩施土家族苗族自治州中心医院肿瘤放疗中心接受治疗原发性肝癌患者108例,随机分为放疗组、联合治疗组各54例,放疗组患者进行放疗,联合治疗组患者使用氟尿嘧啶联合放疗进行治疗。对两组患者肝功能、凝血功能进行检测;酶联免疫吸附实验法检测肝纤维化指标水平,免疫透射比浊法检测LPO、MDA水平,对比两组患者治疗总有效率。结果治疗后联合治疗组患者AST、ALT、APTT、PT、HA、LN、PC-Ⅲ、LPO、MDA水平均低于放疗组(P均=0.001),差异有统计学意义(P<0.05)。联合治疗组治疗总有效率高于放疗组(P=0.023),差异有统计学意义(P<0.05)。结论使用氟尿嘧啶联合放疗对原发性肝癌患者进行治疗,能够改善患者肝功能及凝血功能,减轻患者肝纤维化及氧化应激反应严重程度,治疗效果显著。

Objective To explore the therapeutic effect of fluorouracil combined with radiotherapy on patients with primary liver cancer and its effect on the levels of serum lipid peroxide(LPO)and malondialdehyde(MDA).Methods From March 2016 to March 2017,a total of 108 patients with primary liver cancer were randomly divided into two groups:radiotherapy group and combined treatment group,with 54 cases in each group.The patients in the radiotherapy group were treated with radiotherapy,while the patients in the combined treatment group were treated with fluorouracil combined with radiotherapy.Biochemical assays were used to detect the levels of aspartate aminotransferase(AST),glutamyl transpeptidase(GGT),alanine aminotransferase(ALT),fibrinogen(FIB),activated partial thromboplastin time(APTT),and prothrombin time(PT).The enzyme-linked immunosorbent assay was used to detect serum hyaluronidase(HA),laminin(LN),and type III procollagen(PCIII)levels.The flow cytometry was used to detect T lymphocyte subgroup levels.LPO and MDA were detected by immunoturbidimetry.The total effective rate was compared between the two groups.Results The levels of AST,GGT and ALT in the combined treatment group were significantly lower than those in the radiotherapy group(P<0.05).After treatment,the FIB level in the combined treatment group was higher than that in the radiotherapy group,and the APTT and Pt levels were lower than those in the radiotherapy group(P<0.05).The levels of HA,LN and PCIII in the combined treatment group were lower than those in the radiotherapy group(P<0.05).After treatment,the CD8+level in the combined treatment group was lower than that in the radiotherapy group,while the CD4+and CD3+levels were higher than those in the radiotherapy group(P<0.05).The level of LPO and MDA in the combined treatment group was lower than that in the radiotherapy group(P<0.05).The total effective rate of the combined treatment group was higher than that of the radiotherapy group(P<0.05).Conclusion The treatment of primary liver cancer patients with fluorouracil combined with radiotherapy could improve the liver function and coagulation function,improve the immune function,and reduce the severity of liver fibrosis and oxidative stress response of patients.The effect of the combination treatment was significant.