神经外科术后患者应用单唾液酸四己糖神经节苷脂的合理性分析和不良反应研究

Rationality analysis and adverse reactions of monosialotetrahexosylganglioside in patients after neurosurgery

目的分析我院神经外科术后患者应用单唾液酸四己糖神经节苷脂的合理性与不良反应发生的规律和特点。方法回顾性分析我院2018年10月至2019年10月1107例神经外科术后患者应用过单唾液酸四己糖神经节苷脂的病例,参照其说明书和相关指南进行合理性分析,对不良反应发生率、发生的时间和临床表现等进行分析统计。结果1107例病例中,用药疗程不合理13例(1.17%),用法用量不合理78例(7.05%),滴注速度不合理39例(3.52%),联合用药不合理34例(3.07%)。发生不良反应的有16例(1.44%),主要累及皮肤及其附件、全身和神经系统。其中吉兰巴雷综合征的发生率比已有文献报道高。结论神经外科术后的患者应用单唾液酸四己糖神经节苷脂存在不合理情况,其中用法用量和滴注速度不合理所占比例较大。临床工作中应提高其使用合理性,并严密观察病情变化,及早识别不良反应,尤其是吉兰巴雷综合征的发生,确保患者用药安全。

Objective To analyze the rationality and characteristics of adverse reactions after application of monosialotetrahexosylganglioside in patients after neurosurgery in our hospital.Methods The cases of 1107 patients who had monosialotetrahexosylganglioside after neurosurgery from October 2018 to October 2019 in our hospital were analyzed retrospectively,and the rationality was evaluated according to the drug instruction and relevant guidelines,and the incidence of adverse reactions,the time of occurrence,and clinical manifestation were analyzed.Results There were 16(1.44%)patients had adverse reactions,mainly involving the skin and its attachments,the whole body and the nervous system.The incidence of Guillain-Barrésyndrome was higher than that reported in literatures.Conclusion There are unreasonable phenomenon in the use of monosialotetrahexosylgangliosides in patients after neurosurgery,among which the unreasonable doses and dripping speed account for a large proportion.The rational use of monosialotetrahexosylgangliosides should be improved and we should closely observe the changes in the condition and identify adverse reactions early,especially the occurrence of Guillain-Barrésyndrome,in order to ensure the safe medication in patients.