伊布利特联合胺碘酮转复持续性房颤的有效性及安全性研究

Research on the Efficacy and Safety of Combination Use of Ibutilide and Amiodarone for Cardioversion of Persistent Atrial fibrillation

目的研究伊布利特联合胺碘酮对转复持续性房颤的有效性及安全性。方法选取持续性房颤的患者75例,随机分为研究组(n=39)和对照组(n=36),研究组序贯给予胺碘酮300 mg和伊布利特静脉注射,对照组给予与胺碘酮相同剂量的安慰剂(5%葡萄糖注射液)和伊布利特静脉注射。比较两组的转复率、室性心律失常发生率、f波间期、QT间期和QTc间期的变化。结果研究组与对照组比较,持续性房颤转复成功率为76.9%和58.3%;室性心律失常的发生率分别为1例(2.5%)和17例(47.2%)。结论 (1)静脉应用伊布利特联合胺碘酮对转复持续性房颤的成功率明显优于单独应用伊布利特,联合用药更具有明显的有效性;(2)明显降低了单用伊布利特时室性心律失常的发生率,联合用药提高转复安全性。

OBJECTIVE Observe efficacy and safety of combination use of amiodarone and ibutilide for atrial fibrillation cardioversion. METHODS 75 patients with persistent atrial fibrillation were randomly divided into study group(n=39)and control group(n=36). Study group received injection of 300 mg intravenous amiodarone before ibutilide, and the control group received the corresponding injection of the same amount of glucose before ibutilide. RESULTS The overall rate of arrhythmia cardioversion were 76.9% in study group and 58.3% in control group. Incidence of ventricular arrhythmias were1(2.5%)case in study group and 17(47.2%)cases in control group. CONCLUSION Intravenous injection of amiodarone following ibutilide injection in atrial arrhythmia cardioversion was more effective compared with using ibutilide alone and significantly reduced ventricular arrhythmias incidence.