奥美拉唑结合替硝唑治疗急性肠胃炎的疗效及安全性分析

Efficacy and safety analysis of omeprazole combined with tinidazole in the treatment of acute gastroenteritis

目的探究分析奥美拉唑结合替硝唑治疗急性肠胃炎的疗效及安全性。方法选取90例急性肠胃炎患者作为研究对象,随机分为对照组与观察组,各45例。对照组行奥美拉唑治疗,观察组行替硝唑联合奥美拉唑治疗。对比两组患者治疗效果、临床症状(呕吐、腹痛、腹泻、发热)消失时间、治疗前后炎症因子[血清白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平、不良反应发生情况。结果观察组患者的治疗总有效率95.56%明显优于对照组的82.22%,差异具有统计学意义(P<0.05)。观察组患者的呕吐、腹痛、腹泻、发热消失时间均短于对照组,差异均具有统计学意义(P<0.05)。治疗前,两组患者IL-6、IL-8、TNF-α水平比较差异无统计学意义(P>0.05);治疗后,两组患者IL-6、IL-8、TNF-α水平均低于治疗前,且观察组患者IL-6、TNF-α、IL-8水平均明显低于对照组,差异均具有统计学意义(P<0.05)。观察组患者的不良反应发生率11.11%明显低于对照组的28.89%,差异具有统计学意义(P<0.05)。结论奥美拉唑联合替硝唑治疗急性肠胃炎疗效显著,可快速缓解临床症状,不良发应发生率低,治疗安全性高,值得推广。

Objective To investigate and analyze the efficacy and safety of omeprazole combined with tinidazole in the treatment of acute gastroenteritis.Methods A total of 90 cases of acute gastroenteritis as study subjects were randomly divided into control group and observation group,with 45 cases in each group.The control group was treated by omeprazole,and the observation group was treated by omeprazole combined with tinidazole.The therapeutic effect,clinical symptom(vomiting,abdominal pain,diarrhea,fever)disappearance time,levels of inflammatory factors[serum interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]and adverse reactions before and after treatment were compared between the two groups.Results The total effective rate of treatment 95.56% in the observation group was obviously better than 82.22% in the control group,and the difference was statistically significant(P<0.05).The disappearance time of vomiting,abdominal pain,diarrhea,fever of the observation group was shorter than those of the control group,and their difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in levels of IL-6,IL-8 and TNF-αbetween the two groups(P>0.05).After treatment,the levels of IL-6,IL-8 and TNF-αin the two groups were lower than those before treatment,and the levels of IL-6,IL-8 and TNF-α in the observation group were obviously lower than those in the control group.Their difference was statistically significant(P<0.05).The incidence of adverse reactions 11.11% in the observation group was obviously lower than 28.89%in the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of omeprazole and tinidazole shows remarkable efficacy in the treatment of acute gastroenteritis,which can quickly relieve the clinical symptoms with low incidence of adverse events and high treatment safety.It is worth popularizing.