结直肠癌组织中NF-κB、Notch-1的临床表达意义

Clinical Expression of NF-κB and Notch-1 in Colorectal Cancer

目的探讨与分析结直肠癌组织中核转录因子κB(NF-κB)、Notch-1的临床表达意义。方法选择结直肠癌患者原发癌组织标本(癌症组)与癌旁组织标本(癌旁组),采用免疫组化法检测NF-κB、Notch-1表达情况,调查患者的临床资料、预后并进行相关性分析。结果癌症组的NF-κB、Notch-1表达阳性率分别为75.0%、65.0%,显著高于癌旁组的5.0%和3.3%(P<0.05)。随访到2019年6月,120例患者中死亡20例,生存100例,中位生存时间为(28.33±4.19)个月。NF-κB、Notch-1表达阳性都与结直肠癌的Dukes分期、黏液癌、淋巴结转移、浸润深度、随访预后呈正相关(P<0.05),与组织学分化程度呈负相关(P<0.05)。Cox回归模型分析显示淋巴结转移、Dukes分期、NF-κB、Notch-1表达阳性为影响患者中位生存时间的重要因素(P<0.05)。结论NF-κB、Notch-1在结直肠癌中都呈现高表达状况,与结直肠癌的临床病理特征相关,也与患者的预后生存显著相关。

Objective To investigate and analysis the clinical expression of NF-κB and Notch-1 in colorectal cancer tissues.Methods Select primary cancer tissue specimens(cancer group)and paracancerous tissue specimens(paracancerous group)of colorectal cancer patients.The expression ofκB and Notch-1 were detected by the immunohistochemistry,and the clinical data and prognosis of the patients were investigated and were given correlation analysis.Results The positive rates of NF-κB and Notch-1 expression in the cancer group were 75.0%and 65.0%,respectively,which were significantly higher than those in the paracancerous group(5.0%and 3.3%,respectively)(P<0.05).20 patients were died,100 patients were survived,and the median survival time were(28.33±4.19)months,the positive expression of NF-κB and Notch-1 were positively correlated with Dukes stage,mucinous carcinoma,lymph node metastasis,depth of invasion and prognosis of colorectal cancer(P<0.05),and were negatively correlated with histological differentiation(P<0.05).Cox regression model analysis showed that lymph node metastasis,Dukes stage,NF-κB and Notch-1 expression were important factors affecting the median survival time of patients(P<0.05).Conclusion NF-κB and Notch-1 are highly expressed in colorectal cancer,which are related to the clinicopathological features of colorectal cancer and also significantly related to the prognosis of patients.