摘要
目的评价结扎装置辅助内镜黏膜下切除术(endoscopic submucosal resection with ligating device,ESMR-L)与内镜黏膜下剥离术(endoscopic submucosal dissection,ESD)治疗直径<1.0 cm的直肠神经内分泌肿瘤(rectal neuroendocrine tumors,r-NETS)的安全性与疗效差异。方法回顾性分析内镜下治疗的43名r-NETS患者的临床资料,其中ESMR-L组23例,ESD组20例,并进行内镜随访,研究不同手术方式患者在整块切除率、组织学完整切除率、手术时间、并发症、住院总费用、随访结果等方面的差异。结果2种手术方式的整块切除率均为100%。ESD组中组织学完整切除率略高于ESMR-L组(100%vs 95.6%),但差异性比较无统计学意义(P>0.05)。ESD组的平均手术时间显著长于ESMR-L组(P<0.05),ESD组平均住院时间也明显长于ESMR-L组(P<0.05),ESD组平均住院费用明显高于ESMR-L组(P<0.05)。ESD组中有1例术中肌层损伤,ESMR-L组中有1例迟发出血,内镜下处理后2组均无外科干预。随访期间2组患者均无局部复发及远处转移。结论ESMR-L和ESD均可有效治疗直径<1.0 cm r-NETS,但ESMR-L比ESD手术方式更简单,耗时更短,花费更少。
Objective To compare the difference of efficacy and safety between endoscopic submucosal resection with a ligation device(ESMR-L)and endoscopic submucosal dissection(ESD)for the rectal neuroendocrine tumors of diameter(rNETs)<1.0 cm.Methods 43 patients with rNETs(d<1.0 cm)treated by colonoscopy were analyzed retrospectively.According to different treatment methods,43 patients were divided into ESMR-L group(n=23)and ESD group(n=20).The treatment results of different groups were compared,including baseline characteristics,the rate of en-bloc resection,pathological complete resection,operation time,complications,total hospitalization cost and time,and follow-up results.Results The rate of en-bloc resection was 100%in both groups.The complete endoscopic resection of the ESD group was slightly higher than that of the ESMR-Lgroup(100%vs 95.6%),but the difference was not statistically significant(P>0.05).The average operation time of the ESD group was significantly longer than that of the ESMR-L group(P<0.05).The average hospitalization period of the ESD group was also significantly longer than that of theESMR-L group(P<0.05),and the hospitalization cost of the ESD group was significantly higher than that of the ESMR-L group(P<0.05).There was 1 case of intrinsic muscular layer injury in the ESD group,and 1 case of postoperative bleeding in the ESMR-L group.There was no surgical intervention in both groups after endoscopic treatment.There were no local recurrence and distant metastasis in both groups during the follow-up period.Conclusion Both ESMR-L and ESD can effectively treat small rNETs,but ESMR-L is simpler,less time-consuming and less costly than ESD.
作者
吴利娟
田笑笑
金建军
白艳丽
李慧
WU Lijuan;TIAN Xiaoxiao;JIN Jianjun(The First Affiliated Hospital of Henan University of Science and Technology,Louyang,471003)
出处
《实用癌症杂志》
2020年第4期624-627,共4页
The Practical Journal of Cancer
基金
河南科技大学校级基金(编号:2015YB-060)。