丙泊酚靶控输注对老年腹部恶性肿瘤手术患者炎性指标的影响及安全性分析

Analysis of Inflammatory Index and Safety of Propofol Target Controlled Infusion inElderly Patients Undergoing Abdominal Tumor Surgery

目的观察丙泊酚靶控输注对老年腹部肿瘤手术患者炎性指标的影响及安全性。方法以100例老年腹部肿瘤手术患者为本次研究对象,按照是否术中给予丙泊酚靶控输注将所有患者分为对照组(50例:2%~3%七氟醚持续吸入)与实验组(50例:丙泊酚靶控输注),比较两组患者手术期相关诊疗效果。结果实验组患者术中出血量、平均手术时间、平均住院时间等与对照组比较,差异不明显(P>0.05)。实验组患者术后3 h、术后1天简易智力状态检查量表(MMSE)得分均优于对照组,差异明显(P<0.05)。实验组患者围手术期IL-6、TNF-α等炎性因子水平均明显低于对照组,差异明显(P<0.05)。实验组患者不良反应发生率(6.00%)明显低于对照组,差异明显(P<0.05)。结论老年腹部肿瘤手术患者丙泊酚靶控输注麻醉效果明显优于七氟醚持续吸入麻醉效果。

Objective To observe the inflammatory index and safety of propofol target controlled infusion in elderly patients undergoing abdominal tumor surgery.Methods 100 elderly patients undergoing abdominal tumor surgery were selected as the subjects of this study,All patients were divided into the control group(50 case,2%~3%continuous inhalation of sevoflurane)and the experimental group(50 case,propofol target controlled infusion)according to whether or not to give intraoperative propofol target controlled infusion,The clinical effects of the 2 groups were compared in operation period.Results There was no significant difference in the data of intraoperative blood loss,average operation time and average hospital stay between the experimental group and the control group(P>0.05).3 hours and 1 day after the operation,the MMSE score of the experimental group was higher than that of the control group(P<0.05).During the perioperative,il-6,TNF-α and other inflammatory factors of the experimental group were significantly lower than those of the control group(P<0.05).The incidence of adverse reactions(6.00%)of the experimental group was significantly lower than that of the control group(P<0.05).Conclusion In the elderly patients undergoing abdominal tumor surgery,the anesthetic effect of propofol target controlled infusion is obviously better than that of continuous inhalation of sevoflurane.