卒中后抑郁病因机制研究进展

A review on etiological mechanisms of post-stroke depression

目前我国已是世界上脑卒中风险最大的国家。卒中后抑郁(Post-Stroke Depression,PSD)是脑卒中后最常见的神经精神并发症之一。PSD不仅延长患者功能康复时间,严重影响生活质量,而且显著增加致残率和病死率,给家庭、社会带来沉重负担、负面引导等不良影响。虽然目前证实神经递质、神经内分泌、神经解剖、炎症因子、遗传基因、神经营养因子、氧化应激、肠道菌群、社会心理等与PSD密切相关,但对PSD的具体病因机制尚无统一定论,给疾病的预防和治疗带来严峻考验。

China has been the country with the highest risk of stroke in the world.PSD is one of the most prevalent psychiatric disorder complications after stroke,which not only prolongs the time of patients’functional rehabilitation,but also seriously affects the quality of life,significantly increases the disability and mortality,brings heavy burdens and negative guidance to families and society.Although it has been confirmed that neurotransmitters,neurosecretory systems,neuroanatomical sites,markers of neuroinflammation,genetic markers,neurotrophins,markers of oxidative damage,gut microbiomes,psychology and other factors are closely related to PSD,the specific etiological mechanism of PSD has not been unified,which brings severe tests to the prevention and treatment of it.