复方半枝莲汤治疗失代偿期乙型肝炎肝硬化的临床效果及患者血清T细胞亚群分析

Clinical effect of compound Banzhilian decoction ondecompensated hepatitis b cirrhosis and serum T cell subsets in patients

目的:探讨复方半枝莲汤治疗失代偿期乙型肝炎肝硬化的临床效果。方法:选取2016年1月-2018年1月于通辽市传染病医院进行治疗的失代偿期乙型肝炎肝硬化患者60例,按照随机方式分为两组,对照组为恩替卡韦^+保肝对症的常规治疗;研究组在对照组治疗方式的基础上联合使用复方半枝莲汤,研究对比两组患者临床疗效以及血清T细胞亚群等指标的差异。结果:治疗后研究组和对照组治疗有效率分别为96.7%(29/30)和76.7%(23/30)研究组,临床疗效显著优于对照组(P<0.05);治疗前两组患者乙肝病毒的脱氧核糖核酸(Hepatitis B virus Deoxyribonucleic Acid,HBV-DNA)及肝功能指标无显著变化(P>0.05),研究组治疗后各指标下降程度显著优于对照组(P<0.05);治疗前两组患者CD8^+、CD4^+、CD4^+/CD8^+指标无明显差异(P>0.05),治疗后CD4^+提升,CD8^+下降,CD4^+/CD8^+指标上升,CD8^+、CD4^+、CD4^+/CD8^+指标较对照组更加显著(P<0.05);治疗后研究组和对照组不良反应的发生率分别为6.7%(2/30)和33.3%(10/30),研究组不良反应发生率显著低于对照组(P<0.05)。结论:常规治疗同时联合复方半枝莲汤治疗失代偿期乙型肝炎肝硬化效果显著,可有效改善患者肝功能,抑制HBVDNA的复制,提高免疫功能,且具有良好的治疗安全性。

Objective:To investigate the clinical effect of compound Banzhilian decoction(复方半枝莲汤)on decompensated hepatitis b cirrhosis.Methods:60 patients with decompensated hepatitis b cirrhosis who were treated in our hospital from January 2016 to January 2018 were selected and randomly divided into two groups.On the basis of the treatment methods of the control group,the study group received the combination of the compound Banzhilian decoction,and the clinical efficacy of the two groups of patients and the differences in serum T cell subsets and other indicators were studied and compared.Results:The effective rates were 96.7%(29/30)in the post-treatment study group and 76.7%(23/30)in the control group respectively.The clinical efficacy of the study group was significantly better than that in the control group(P<0.05).There was no significant change in HBV-DNA and liver function indexes in the two groups before treatment(P>0.05),and the decrease degree of each index in the study group was significantly better than that in the control group(P<0.05).There were no significant differences in CD8^+,CD4^+,CD4^+/CD8^+between the two groups before treatment(P>0.05).After treatment,CD4^+increased,CD8^+decreased,and CD4^+/CD8^+increased.The improvement of CD8^+,CD4^+,and CD4^+/CD8^+in the study group was more significant than that in the control group(P<0.05).After treatment,the incidence of adverse reactions in the study group and the control group was 6.7%(2/30)and 33.3%(10/30)respectively,and the incidence of adverse reactions in the study group was significantly lower than that in the control group(P<0.05).Conclusion:Conventional therapy combined with compound Banzhilian decoction has a significant effect in the treatment of decompensated hepatitis b cirrhosis,which can effectively improve patients'liver function,inhibit HBV-DNA replication,improve immune function,and has good therapeutic safety.