胃复春联合叶酸及替普瑞酮治疗慢性萎缩性胃炎的效果观察

Observation of curative efficacy of Weifuchun,folic Acid and teprenone in treatment of chronic atrophic gastritis

【目的】观察胃复春联合叶酸及替普瑞酮治疗慢性萎缩性胃炎的效果和对慢性萎缩性胃炎患者血清胃泌素-17、胃蛋白酶原的影响。【方法】选取2017年1月至2018年1月在我院就诊的150例慢性萎缩性胃炎(幽门螺旋杆菌阴性)患者为研究对象,随机分成3组(胃复春组、胃复春联合替普瑞酮组、胃复春联合替普瑞酮及叶酸组),每组50例。治疗6个月后比较3组患者的临床疗效,胃镜病理积分,以及血清胃泌素-17、胃蛋白酶原水平。记录并发症发生情况。【结果】治疗后,胃复春联合替普瑞酮及叶酸组的总有效率明显优于其他两组(P<0.05)。3组患者均有1例出现不良反应,差异无统计学意义(P>0.05)。【结论】胃复春联合替普瑞酮及叶酸对慢性萎缩性胃炎的临床疗效显著,值得临床推广应用。

【Objective】To observe the curative efficacy of Weifuchun combined with folic acid and teprenone on chronic atrophic gastritis(CAG)and the its effect on serum gastrin-17(G-17)and pepsinogen(PG)in patients with CAG.【Methods】A total of 150 patients with HP-negative CAG were selected in our hospital from January 2017 to January 2018 and randomly divided into Weifuchun group,Weifuchun combined with teprenone group and Weifuchun combined with teprenone and folic acid group,50 cases per group.After 6 months of treatment,the clinical curative efficacy,pathological scores of gastroscopy,levels of serum G-17 and PG were compared among the three groups.The incidence rate of complications was recorded.【Results】After the treatment,the total effective rate in the Weifuchun combined with teprenone and folic acid group was significantly higher than those in the other two groups(P<0.05).There was one case of adverse reaction in each of the three groups,which was not statistically significant(P>0.05).【Conclusion】Weifuchun combined with teprenone and folic acid in the treatment of CAG is of significant clinical curative efficacy,which is worthy to be popularized.