血塞通联合羟苯磺酸钙治疗老年性黄斑变性的临床疗效及对患者血液流变学、超氧化物歧化酶水平的影响

Clinical efficacy of Xuesaitong combined with calcium dobesilate in the treatment of senile macular degeneration and its effect on hemorheology and superoxide dismutase levels

目的探讨血塞通联合羟苯磺酸钙胶囊治疗老年性黄斑变性患者的临床疗效以及对患者血液流变学、超氧化物歧化酶(SOD)水平的影响。方法选取2016年10月至2018年8月在我院接受治疗的老年性黄斑变性患者86例,采用随机数字法分为观察组和对照组,每组43例。对照组患者采用羟苯磺酸钙胶囊治疗,观察组患者给予羟苯磺酸钙胶囊联合血塞通治疗,疗程3个月。比较两组患者的临床疗效、血液流变学指标及SOD水平变化情况。结果治疗3个月后,观察组患者的治疗总有效率(97.7%)显著高于对照组(81.4%),差异有统计学意义(P<0.05);两组患者的全血低切黏度、全血中切黏度、全血高切黏度、血浆黏度水平均显著降低,观察组的水平均显著低于对照组,差异有统计学意义(P<0.05);两组患者的SOD水平均显著升高,观察组患者的水平显著高于对照组,差异有统计学意义(P<0.05)。结论血塞通联合羟苯磺酸钙胶囊治疗老年性黄斑变性临床疗效显著,能有效改善患者的血液流变学指标,提高患者的抗氧化能力。

Objective To investigate the clinical efficacy of Xuesaitong combined with calcium dobesilate capsules in the treatment of senile macular degeneration and its effects on hemorheology and superoxide dismutase(SOD)level.Methods A total of 86 patients with senile macular degeneration admitted to our hospital from October 2016 to August 2018 were selected and divided into observation group and control group according to the random number method,with 43 cases in each group.Patients in the control group were administered calcium dobesilate capsules and the observation group with calcium dobesilate capsules combined with Xuesaitong,for three-month treatment courses.The clinical efficacy,hemorheological indexes and SOD level between the two groups were compared.Results After 3 months of treatment,the total effective rate of treatment in the observation group(97.7%)was significantly higher than that in the control group(81.4%),and the difference was statistically significant(P<0.05).The levels of low shear viscosity of whole blood,moderate shear viscosity of whole blood,high shear viscosity of whole blood,and plasma viscosity of the two groups significantly decreased.The levels of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).SOD level in the two groups increased significantly,and the level in the observation group was significantly higher than that in the control group,with statistically significant difference(P<0.05).Conclusion The clinical efficacy of Xuesaitong combined with calcium dobesilate capsules in treating senile macular degeneration is prominent.It can effectively improve the hemorheological indexes,and increase the antioxidant capacity of patients.