左氧氟沙星联合抗结核化疗对复治涂阳肺结核的效果观察

Effects of Levofloxacin combined with anti-tuberculosis chemotherapy on retreatment of smear-positive pulmonary tuberculosis

目的:观察左氧氟沙星联合抗结核化疗对复治涂阳肺结核的临床效果。方法:选取收治的54例复治涂阳肺结核患者作为研究对象,根据不同治疗方法分为对照组与观察组,每组27例。对照组予单纯抗结核化疗治疗,观察组在对照组基础上联合左氧氟沙星治疗,比较两组临床疗效、治疗前后免疫功能指标水平及不良反应发生率。结果:治疗后,观察组治疗总有效率为96.30%,高于对照组的74.07%,差异有统计学意义(P<0.05);两组CD3+、CD4+、CD8+、CD4+/CD8+水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:与常规抗结核化疗比较,左氧氟沙星联合抗结核化疗对复治涂阳肺结核患者的疗效较好,可改善患者的免疫功能指标,且不良反应发生率较低。

Objective:To observe effects of Levofloxacin combined with anti-tuberculosis chemotherapy on retreatment of smear-positive pulmonary tuberculosis.Methods:54 admitted patients with smear-positive pulmonary tuberculosis were selected as the research objects,and were divided into control group and observation group according to different treatment methods,27 cases in each group.The control group was treated with anti-tuberculosis chemotherapy alone,while the observation group was combined with Levofloxacin on the basis of that of the control group.The clinical efficacy,the levels of immune function indexes and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the total effective rate in the observation group was 96.30%,which was higher than 74.07%in the control group,and the difference was statistically significant(P<0.05).The levels of CD3+,CD4+,CD8+and CD4+/CD8+in the two groups were higher than those before the treatment;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compared with conventional antituberculosis chemotherapy regime,Levofloxacin combined with anti-tuberculosis chemotherapy has a better effect in the retreatment of smear-positive pulmonary tuberculosis patients.It can improve the immune function indexes of these patients with a lower incidence of adverse reactions.