探讨隐睾患儿抗精子抗体(AsAb)与手术、绒毛膜促性腺激素(HCG)应用的相关性及术后血清雌二醇(E2)、睾酮(T)水平的变化

Correlation of Antisperm Antibody(AsAb)with Cryptorchidism in Children with Surgery,Chorionic Gonadotropin(HCG)Application,and Changes in Serum Estradiol(E2)and Testosterone(T)Levels after Surgery

目的:探究隐睾患儿应用手术、绒毛膜促性腺激素(HCG)和抗精子抗体(AsAb)之间的相关性和术后睾酮(T)和血清雌二醇(E2)的变化情况。方法:本次实验对象选在2016年1月至2019年1月期间在本院进行睾丸下降固定术的73例隐睾患儿,将其归为实验组,选择同一时期在本院进行腹股沟手术的18例腹股沟疝患儿为手术对照组,18例非手术患儿为正常对照组,检查并分析每组实验对象的T、E2以及AsAb水平。结果:在T水平上,实验组、正常对照组、手术对照组对比,HCG组和非HCG组的AsAb阳性率对比,差异无统计学意义(P>0.05)。在E2水平上,实验组高于正常对照组、手术对照组,手术对照组的AsAb阳性率显著高于正常对照组,差异有统计学意义(P<0.05)。实验组AsAb阳性患者全部为IgG阳性,IgG、IgA、IgM均为阳性的为3例,在手术对照组中,AsAb阳性患者全部为IgG阳性。结论:隐睾患儿产生抗精子抗体和内分泌紊乱、血睾屏障密切联系,但是使用HCG无明显影响。

Objective:To investigate the correlation between surgery,chorionic gonadotropin(HCG)and anti-sperm antibody(AsAb)in children with cryptorchidism and changes of postoperative testosterone(T)and serum estradiol(E2)Happening.Methods:A total of 73 children with cryptorchidism who underwent testicular reduction in our hospital from January 2016 to January 2019 were enrolled in this study.They were assigned to the experimental group and selected for groin surgery in our hospital during the same period.The 18 children with inguinal hernia were in the surgical control group,and 18 non-surgical children were in the normal control group.The T,E2 and AsAb levels of each group were examined and analyzed.Results:At the T level,there was no significant difference in the positive rate of AsAb between the experimental group,the normal control group and the surgical control group,and the difference between the HCG group and the non-HCG group(P>0.05).At the E2 level,the positive rate of AsAb in the experimental group was higher than that in the normal control group and the surgical control group.The positive rate of AsAb was significantly higher than that in the normal control group(P<0.05).All AsAb-positive patients in the experimental group were all IgG-positive,and 3 cases were positive for IgG,IgA,and IgM.In the surgical control group,all AsAb-positive patients were IgG-positive.Conclusion:Children with cryptorchidism have anti-sperm antibodies and endocrine disorders,and the blood testis barrier is closely related,but there is no significant effect on the use of HCG.