尿糖、尿微量白蛋白联合检验对糖尿病早期肾损伤的诊断作用分析

Analysis of combined test of urinary glucose and urinary microalbumin in the diagnosis of early renal damage in diabetes mellitus patients

目的探究尿糖、尿微量白蛋白联合检验对糖尿病早期肾损伤的诊断价值。方法选取42例糖尿病早期肾损伤患者作为观察组, 42例糖尿病非肾损伤患者作为对照组, 42例健康体检患者作为健康组。检测对比三组尿糖、尿微量白蛋白水平,统计尿糖单独检验、尿微量白蛋白单独检验及尿糖、尿微量白蛋白联合检验的诊断结果。对比尿糖单独检验、尿微量白蛋白单独检验及尿糖、尿微量白蛋白联合检验的敏感性、特异性及准确率。结果观察组尿糖、尿微量白蛋白水平分别为(3.38±0.45)mmol/L、(36.53±6.15)mg/L;对照组尿糖、尿微量白蛋白水平分别为(2.91±0.36)mmol/L、(24.85±4.73)mg/L;健康组尿糖、尿微量白蛋白水平分别为(1.15±0.28)mmol/L、(14.13±2.84)mg/L;观察组尿糖、尿微量白蛋白水平均显著高于对照组和健康组,对照组显著高于健康组,差异有统计学意义(P<0.05)。尿糖单独检验检出阳性72例,阴性54例;尿微量白蛋白单独检验检出阳性34例,阴性92例;尿糖、尿微量白蛋白联合检验检出阳性40例,阴性86例;病理结果显示:阳性42例,阴性84例。尿微量白蛋白单独检验及尿糖、尿微量白蛋白联合检验的特异性、准确率显著高于尿糖单独检验,尿糖、尿微量白蛋白联合检验的敏感性、准确率显著高于尿微量白蛋白单独检验,差异有统计学意义(P<0.05)。结论尿糖、尿微量白蛋白是糖尿病早期肾损伤的重要指标,尿糖、尿微量白蛋白联合检验诊断糖尿病早期肾损伤效果良好,显著优于单独检验,宜于临床推广。

Objective To investigate the diagnostic value of combined test of urinary glucose and urinary microalbumin in the diagnosis of early renal damage in diabetic patients. Methods There were 42 diabetes mellitus patients with early renal damage selected as the observation group, 42 diabetes mellitus patients without early renal damage selected as the control group, and another 42 healthy physical examination patients as healthy group. The levels of urinary glucose and urinary microalbumin in three groups were measured and compared, and the diagnosis results of separate urinary glucose test, separate urinary microalbumin test and combined test of urinary glucose and urinary microalbumin were statistically analyzed. The sensitivity, specificity and accuracy of separate urinary glucose test, separate urinary microalbumin test and combined test of urinary glucose and urinary microalbumin were compared. Results The levels of urinary glucose and urinary microalbumin were(3.38± 0.45) mmol/L and(36.53±6.15) mg/L respectively in the observation group, which were(2.91±0.36) mmol/L and(24.85±4.73) mg/L in the control group, and(1.15±0.28) mmol/L and(14.13±2.84) mg/L in healthy group. The levels of urinary glucose and urinary microalbumin in the observation group were significantly higher than those in the control group and healthy group, and the control group was significantly higher than the healthy group. The difference was statistically significant(P<0.05). 72 cases were positive and 54 cases were negative in separate urinary glucose test, 34 cases were positive and 92 cases were negative in separate urinary microalbumin test, 40 cases were positive and 86 cases were negative in combined test of urinary glucose and urinary microalbumin. Pathological results showed that 42 cases were positive and 84 cases were negative. The specificity and accuracy of separate urinary microalbumin test and combined test of urinary glucose and urinary microalbumin were significantly higher than those of separate urinary glucose test, and the specificity and accuracy of combined test of urinary glucose and urinary microalbumin were significantly higher than those of separate urinary microalbumin test. The difference was statistically significant(P<0.05). Conclusion Urinary glucose and urinary microalbumin are important indicators of early renal damage in diabetes. The combined test of urinary glucose and urinary microalbumin has a good effect in diagnosing early renal damage in diabetes mellitus, which is significantly better than separate test and is suitable for clinical promotion.