两株南极枝孢霉属真菌Cladosporium sp.NJF4和NJF6的次级代谢产物研究

SECONDARY METABOLITES FROM THE ANTARCTIC FUNGI CLADOSPORIUM SP.NJF4 AND NJF6

南极因其独特的自然环境成为潜在、重要的微生物资源库,是产生新型生物活性物质和先导化合物菌株的潜在种源地,南极微生物正在成为创新药物研究新的重要资源。虽然近年来对南极微生物次级代谢产物的研究逐渐增加,但与温带和热带微生物研究相比仍处于初级阶段。对从南极普里兹湾海洋沉积物中获得的两株枝孢霉属真菌Cladosporium sp.NJF4和NJF6进行次级代谢产物分离及结构鉴定,获得20个化合物。化合物结构类型包括甾醇(1)、倍半萜类(7-8)、生物碱类(9-14)、二酮哌嗪(2-5、15-17)、芳香酸(6、18-19)等,其中倍半萜类(7-8)为首次从枝孢霉属真菌中分离得到,以上研究将为丰富南极微生物次级代谢产物库奠定一定的研究基础。

Antarctic microorganisms exhibit considerable uniqueness and biodiversity because of their harsh and special habitat.Their secondary metabolites have become an important source of bioactive substances.Research on polar microbial secondary metabolites has gradually increased in recent years,but still lags behind temperate and tropical microbial research.We conducted chemical analyses on two fungi(Cladosporium sp.NJF4 and NJF6)in marine sediments from Prydz Bay,Antarctica.Twenty compounds were isolated,including sterol(1),sesquiterpenes(7-8),alkaloids(9-14),diketopiperazines(2-5,15-17),and aromatic acids(6,18-19).The sesquiterpenoids(7-8)were isolated from this genus for the first time.This study provides a new theoretical basis to fully exploit the metabolic potential of the Antarctic microorganisms,and will play an important role in promoting research on the medicinal value of polar microbial resources.