维生素D与儿童支气管哮喘

Vitamin D and childhood asthma

维生素D对钙吸收及骨代谢起重要作用。越来越多的研究发现,维生素D还参与多种感染、炎症及免疫反应的调节过程。维生素D还对多种细胞有重要的调节作用。维生素D不足和缺乏在世界范围内均很普遍,在支气管哮喘儿童中这一现象更加显著。支气管哮喘的病理生理学表现为慢性炎症、气道高反应性和气道重塑。维生素D可能影响哮喘的发生、发展过程。文章阐述了维生素D与哮喘发病率的相关性、维生素D影响哮喘的发病机制及维生素D辅助治疗儿童支气管哮喘的疗效。

Vitamin D plays an important role in calcium absorption and bone metabolism.More and more studies have found that vitamin D is also involved in the modulation of infection,inflammatory and immune responses.Vitamin D also plays an important role in regulating a variety of cells.Vitamin D insufficiency and deficiency are common worldwide,which is more common in children with bronchial asthma.The pathophysiology of bronchial asthma is chronic inflammation,airway hyperresponsiveness and airway remodeling.Vitamin D may affect the occurrence and development process of asthma.This review summarized the correlation between vitamin D and the morbidity of asthma,the mechanisms of vitamin D affecting asthma,and the clinical effects of vitamin D as an adjuvant therapy for childhood asthma.