摘要
This study investigated Linzhou County in Tibet, which currently hosts the most serious outbreak of Kashin-Beck disease(KBD) in China. This study uses the geographical detector(GeoDetector) algorithm to measure the influences that several risk factors have on KBD prevalence and validates the spatial analysis results with environmental chemistry. Based on a comprehensive examination of 10 potentially related spatial factors and an environmental chemistry analysis of the soil-water-grain-human biogeochemical cycle in the local KBD and non-KBD villages, four main conclusions are drawn.(1) KBD in Linzhou County is a consequence of multiple interrelated environmental factors, of which the most important controlling factor is the stratum factor.(2) The concentrations of selenium(Se) in all environmental media(soil, water, and food) and human tissue in the KBD villages in Linzhou County are lower than those of the non-KBD villages.(3) The intake of Se and chromium(Cr) by local residents is seriously insufficient, especially the average daily dose by ingestion(ADD) for Se in the KBD village, which is only about 4% of the World Health Organization(WHO) recommended lower limit for adult elemental intake.(4) We speculate that the main cause for the local KBD outbreak is a lack of Se in the stratum. This absence leads to a serious Se deficiency in the local population through ecosystem migration and transformation, which will eventually lead to an endemic biogeochemical Se deficiency.
西藏林周县是我国大骨节病(KBD)患病较为严重的地区之一,本文将林周县作为研究区,通过使用地理探测器(GeoDetector)量化分析KBD患病率风险因子的影响,并使用环境化学方法验证空间分析结果。通过对10个潜在影响因子的分析以及对当地KBD患病村和非患病村的土壤-水-粮食-人这一生物地球化学循环的环境化学分析,结果表明:(1)林周县KBD由一组多重且交互作用的环境影响因子共同作用影响,其中最重要的控制因子是地层因子;(2)所有环境介质(土壤、水、谷物)及人体组织中的硒元素浓度在KBD患病区均低于非患病区;(3)当地居民对硒和铬的摄入严重不足,尤其是KBD患病村中居民硒元素平均日摄入量(ADD)大约仅为世界卫生组织(WHO)建议的成人基本摄入量下限的4%;(4)我们推测,当地居民患病主要是由于地层这一影响因子,这是由于通过生态系统的迁移转化导致当地人口严重硒缺乏,最终导致地方性生物地球化学硒缺乏。
基金
The Key Research and Development and Transformation Program of Tibet(XZ201901NB08)
The Major Science and Technology Project of Tibet(XZ201901NA03,XZ201801NA02).
