牙源性腺样瘤15例临床特点及预后分析

Clinical manifestation and prognosis of adenomatoid odontogenic tumor:an analysis of 15 cases

目的 对牙源性腺样瘤患者的临床资料进行回顾性分析,对其诊断及治疗方法进行归纳和总结.方法 收集山东大学齐鲁医院口腔颌面外科2011年7月至2019年7月间牙源性腺样瘤的患者,整理牙源性腺样瘤的临床表现、诊断及治疗方法,对患者预后情况进行随访,归纳肿瘤的发生规律与治疗方法.按肿瘤发生的位置,将患者分为上颌组与下颌组,利用Fisher确切概率法,检验患者性别、年龄以及原发肿瘤大小与肿瘤发生位置之间的关系.结果 共收集牙源性腺样瘤病例15例.其中7例男性患者,8例女性患者;发生在上颌者9例,发生在下颌者6例.Fisher确切概率法检验,15例患者中,直径>3 cm的牙源性腺样瘤多发于下颌骨.患者治疗均采用肿瘤刮除术,治疗效果良好.患者随访5个月~8年,预后均良好,无复发,无严重并发症.结论 牙源性腺样瘤临床少见,较难得出具体诊断,需要病理检查方能明确诊断.对牙源性腺样瘤而言,刮除术治疗效果可靠,患者预后良好.

Objective To explore the clinical manifestation,diagnosis,treatment and prognosis of adenomatoid odon-togenic tumor(AOT).Methods The clinical data of AOT patients treated during July 2011 and July 2019 were retro-spectively analyzed,including clinical manifestation,diagnosis,treatment and prognosis.The patients were divided into maxillary group and mandible group based on the site of tumor.The association among tumor size,tumor site,patients gender and age was analyzed with Fisher s exact probability test.Results Altogether 15 cases were enrolled,including 7 male and 8 female.There were 9 in the maxillary group and 6 in the mandible group.Statistical analysis revealed that-tumor with diameters>3 cm were more likely to occur in the mandible.All cases received curettage and had good treat-ment effects.During the follow-up of 5 months to 8 years,all patients showed good prognosis,and no serious complications or recurrence were observed.Conclusion Adenomatoid odontogenic tumor is rare and pathological examination is necessary for confirmation.Curettage is an effective treatment which has favorable therapeutic effects.