沙眼衣原体持续感染与Rab蛋白关系的研究进展

The Relationship Between Chlamydia Trachomatis Infection and Rab Proteins

沙眼衣原体(chlamydia trachomatis,CT)是专性细胞内寄生微生物,在不利于生长的条件下可进入持续感染状态,并引起输卵管性不孕及管性妊娠等严重后遗症,但目前对持续感染的诊治尚未得到有效解决。沙眼衣原体需要通过以囊泡运输为主的途径来获取营养物质以维持生长和复制。已知Rab蛋白家族是囊泡运输的主要调控因子,对沙眼衣原体的生长复制和包涵体的发育都起到重要的作用。通过前期研究已发现多种Rab蛋白在沙眼衣原体持续感染细胞中的表达与急性感染相比升高。Rab蛋白或将为鉴别沙眼衣原体感染状态及持续感染的治疗提供新思路。

Chlamydia trachomatis(Ct)is an endoparasitism microorganism.It can induce persistent infection under bad growth conditions,and cause severe sequelae such as tubal infertility and pregnancy.But the diagnosis and treatment of persistent infection have not been effectively solved.The growth and replication of Ct through vesicle trafficking.The rab GTP-binding proteins is the major regulators of vesicle trafficking and play an important role in the growth and replication of Ct as well as the development of Chlamydial inclusion.Previous studies have found that the expression levels of several Rab proteins are higher in persistently infected cells than in acutely infected.Rab proteins may be a marker for identifying and treatment of persistent infection with Ct.