人巨细胞病毒主要编码蛋白生物学功能的研究进展

Research progress of biological functions of the major proteins encoded by human cytomegalovirus

人巨细胞病毒(human cytomegalovirus,HCMV)感染是全球范围内导致出生缺陷和发育异常的主要原因之一,可使多系统多器官受累,危害较大.HCMV基因组可编码多种功能的蛋白,在病毒感染过程中,需要病毒自身及宿主免疫调节基因帮助其完成复制,这种编码蛋白和宿主细胞因子之间的相互作用决定了病毒的最终命运.了解这些病毒基因编码蛋白的生物学功能及潜在作用机制有助于发现新的抗病毒药物,对减轻致病危害具有重要意义.该文就HCMV主要编码蛋白的生物学功能等方面进一步阐明病毒DNA复制以及感染过程的机理.

Human cytomegalovirus(HCMV)infection is one of the major causes of birth defects and developmental abnormalities worldwide.It can cause multi-system and multi-organ disease with great harm.HCMV genome can encode multiple functional proteins.In the process of virus infection,the virus itself and host immune regulatory genes are used to help them replicate.The interaction between the encoding proteins and host cytokines determines the final fate of the virus.Understanding the biological functions and potential mechanisms of proteins encoded by these viral genes will help to discover new antiviral drugs,which is of great significance to reduce the pathogenic hazards.In this paper,the mechanism of viral DNA replication and infection process will be further elucidated in terms of the biological functions of the major proteins encoded by HCMV.