维生素D水平对早产儿肺发育的影响

Effects of vitamin D levels on lung development in premature infants

早产儿肺发育包括肺泡细胞分化、肺血管发育、肺泡成熟等,维生素D对早产儿肺发育有重要的意义.研究发现,早产儿生后多处于维生素D缺乏或不足状态.低维生素D水平,维生素D结合蛋白、维生素D受体的基因多态性增加了支气管肺发育不良及新生儿呼吸窘迫综合征的发生率.维生素D通过促进肺血管发育、减少肺泡上皮炎性损伤、促进肺泡成熟等调节早产儿肺发育,减少了支气管肺发育不良、新生儿呼吸窘迫综合征、肺动脉高压的风险.该文就维生素D与早产儿肺发育的关系进行综述.

Lung development in premature infants includes alveolar cell differentiation,pulmonary vascular development,alveolar maturation.Vitamin D plays an important role in lung development in premature infants.Studies suggest that premature infants are often deficient or insufficiency in vitamin D.Low vitamin D levels,vitamin D binding protein polymorphisms,and vitamin D receptor gene polymorphisms increase the incidence of bronchopulmonary dysplasia and neonatal respiratory distress syndrome.Vitamin D regulates lung development in premature infants by promoting pulmonary vascular development,reducing inflammatory damage to alveolar epithelial cells,and promoting alveolar maturation,thereby reducing the risk of bronchopulmonary dysplasia,neonatal respiratory distress syndrome,and persistent pulmonary hypertension of newborn.This article reviews the relationship between vitamin D and lung development in premature infants.