补肝养肾汤治疗肝肾不足型强直性脊柱炎临床研究

Clinical Study on Bugan Yangshen Tang for Ankylosing Spondylitis of Liver and Kidney Deficiency Type

目的:研究补肝养肾汤对肝肾不足型强直性脊柱炎患者临床症状、炎症指标及临床疗效的影响。方法:将60例强直性脊柱炎患者按随机数字表法分为对照组和治疗组各30例。对照组给予基础治疗和功能锻炼治疗,治疗组在对照组基础上加用补肝养肾汤治疗。统计分析2组主要症状评分和主要体征,检测血清血沉(ESR)、C-反应蛋白(CRP)、血清免疫球蛋白A(IgA)水平。结果:治疗组总有效率为93.33%,高于对照组70.00%(P<0.05)。治疗前,2组腰骶疼痛、腰脊活动受限、晨僵评分比较,差异无统计学意义(P>0.05)。治疗后,2组腰骶疼痛、腰脊活动受限、晨僵评分较治疗前降低(P<0.05),且治疗组腰骶疼痛、腰脊活动受限、晨僵评分低于对照组(P<0.05)。治疗前,2组枕墙距、指地距、胸廓活动度比较,差异无统计学意义(P>0.05)。治疗后,2组指地距较治疗前降低,胸廓活动度较治疗前升高;且治疗组指地距低于对照组;差异均有统计学意义(P<0.05)。治疗前,2组ESR、CRP及IgA水平比较,差异无统计学意义(P>0.05)。治疗后,2组ESR、CRP及IgA水平较治疗前升高(P<0.05),且治疗组ESR、CRP及IgA水平低于对照组(P<0.05)。结论:补肝养肾汤可以改善强直性脊柱炎患者临床症状及炎症指标,提高患者生活质量。

Objective:To study the effect of Bugan Yangshen tang for ankylosing spondylitis of liver and kidney deficiency type on clinical symptoms,inflammatory indexes and clinical effect.Methods:A total of 60 cases of patients with ankylosing spondylitis were divided into the control group and the treatment group according to the random number table method,30 cases in each group.The control group was given basic treatment and functional exercise,and the treatment group was additionally given Bugan Yangshen tang based on the treatment of the control group.The main symptom scores and main signs in the two groups were recorded and analyzed,and the levels of erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and immunoglobulin A(IgA)in serum were detected.Results:The total effective rate was 93.33%in the treatment group,being higher than that of 70.00%in the control group(P<0.05).Before treatment,compared the scores of lumbosacral pain,limitation of lumbar spinal cord movement and morning stiffness in the two groups,there was no significance in the difference(P>0.05).After treatment,the above scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the treatment group were lower than those in the control group(P<0.05).Before treatment,compared the occiput to wall distance,finger to floor distance and chest expansion in the two groups,there was no significance in the difference(P>0.05).After treatment,the finger to floor distance in the two groups was decreased and the chest expansion was increased when compared with those before treatment;and the finger to floor distance in the treatment group was shorter than that in the control group,differences being significant(P<0.05).Before treatment,compared the levels of ESR,CRP and IgA in the two groups,there was no significance in the difference(P>0.05).After treatment,the above levels in the two groups were increased when compared with those before treatment(P<0.05),and the above levels in the treatment group were lower than those in the control group(P<0.05).Conclusion:The application of of Bugan Yangshen tang can improve the clinical symptoms and inflammatory indexes of patients with ankylosing spondylitis and enhance their quality of life.