肝细胞癌免疫治疗的现状和展望

Current situation and prospect of immunotherapy for hepatocellular carcinoma

肝细胞癌因其发病率和病死率较高,已成为关乎全民健康的严重问题。肝细胞癌的治疗方法众多,近年来免疫治疗的兴起为肝细胞癌的治疗提供了新武器,其实用价值亦得到越来越多的肯定和关注。肝细胞癌的免疫治疗经历了最初的细胞毒性药物、小分子抑制剂到现在的免疫检查点抑制剂,促进肿瘤治疗的模式发生重大改变。同时,应重视免疫相关不良事件的管理和治疗,通过建立多学科诊断与治疗团队促进和提高肝细胞癌的综合治疗水平,从根本上提高疗效,造福患者。

Because of high morbidity and mortality,hepatocellular carcinoma(HCC)has become a serious crisis related to the health of the whole people.There are many treatment methods for HCC.In recent years,the rise of immunotherapy has provided a new weapon for the treatment of HCC,and its practical value has been more and more recognized and concerned.The immunotherapy for HCC has experienced from the initial cytotoxic drugs and small molecule inhibitors to the present immunosuppressive checkpoint inhibitors,and the mode of promoting tumor therapy has been changed greatly.At the same time,we should pay attention to the management of immune related adverse events,improve the comprehensive treatment level of HCC through the establishment of multi-disciplinary diagnosis and treatment team,and fundamentally improve the efficacy and benefit of patients.