多环型Xanthone类天然产物的合成研究进展

Synthetic Progress of Polycyclic Xanthone

多环型xanthone类天然产物是一类具有高度氧化态和六环骨架结构的天然产物.目前分离得到的此类化合物主要来源于放线菌.由于这类化合物具有结构特独、广泛的抗细菌活性、一定程度的抗真菌活性以及良好的抗肿瘤活性,吸引了大量有机合成和药物化学等领域学者的关注.近十年来,相关的生物和化学合成以及药物化学研究报道明显增多,主要总结了多环型xanthone类天然产物的合成研究进展.

Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated angular hexacyclic frameworks.In the last decade,there has been a noticeable increase in reports on both synthetic and pharmacological investigations of this class of natural molecules due to their unique chemical structures and biological activities.Most members of this class of molecules show strong activities towards Gram-positive bacteria,including methicillin-resistant Staphylococcus aureus,potent antifungal activity and antitumour activity.The synthetic studies of some members of this class of natural products is summarized.