氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3+2]环加成反应:螺吡唑类化合物的合成

[3+2]Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines:Synthesis of Sipropyrazole Compounds

采用具有环外双键的二氢苯并呋喃二酮类化合物和氰基亚胺的[3+2]环加成反应,在温和条件下,以高产率(78%~94%)和高非对映选择性(>20∶1dr)构建了一系列具有螺环结构的吡唑类化合物.

The[3+2]cycloaddition of methylenedihydrobenzofbrandiones and nitrilimines worked efficiently in CHC13 at room temperature in the presence of Et3N,producing biologically interesting spirocyclic pyrazole derivatives in high yield(78%?94%)with excellent diastereoselectivity.