零原核来源胚胎的研究进展

Research progress on nonpronuclear embryos

在辅助生殖工作中我们经常遇到卵子没有出现双原核但有2个极体,称为零原核,这可能是由于原核出现提前或者延后而导致未能在特定的原核观察时间点进行受精情况判断.由于目前零原核来源胚胎的临床应用仍存在困惑与争议,大部分中心往往选择废弃,这在一定程度上造成胚胎浪费,从而降低卵子的利用率.近年来,零原核来源胚胎越来越受到辅助生殖技术专家们的关注并取得一定的研究进展.本文就零原核来源胚胎的发生机制、影响因素、遗传属性、发育潜能、临床结局等方面的研究进展做一综述,旨在为零原核来源胚胎的合理应用提供参考.

In assisted reproductive technology(ART),there is a common occurrence that mature oocytes have two polar bodies without two pronuclei after insemination,which named nonpronuclear.The pronuclei of those oocytes may appear in advance or delay at the time of fertilization checking,so the assessment of fertilization is inconclusive.Due to the confusion and controversy of nonpronuclear-derived embryos(named nonpronuclear embryos)in clinical application at present,nonpronuclear embryos are usually discarded which may result in wasting available embryos even decreasing the utilization of the eggs.In recent years,nonpronuclear embryos get more and more attention in ART and have made certain research progress.The aim of this review is to summarize the mechanisms,influence factors,inheritance,embryonic development,clinical outcomes,and other applications about nonpronuclear embryos.The review may provide more basis for the reasonable application.