人脐带间充质干细胞用于衰老相关疾病治疗的研究进展

Research progress of aging-related diseases treatment of human umbilical cord mesenchymal stem cells

随着干细胞移植技术的发展,通过输入干细胞进行抗衰老治疗或治疗退行性疾病成为人们研究的热点。人脐带间充质干细胞(human umbilical cord mesenchymal stem cells,HUCMSCs)是一种存在于脐带沃顿胶以及血管周围组织中的独特前体细胞,具有自我更新和多向分化潜能。目前大量科学研究显示HUCMSCs通过再生和修复衰老的细胞、组织和器官达到抗衰老作用。该文对HUCMSCs的生物学特性、组织再生修复作用和抗衰老治疗机制的研究进展进行了详细回顾,并对目前HUCMSCs临床前研究现况进行了总结,提示HUCMSCs是一种具有良好应用潜力和价值的干细胞类型。

With the development of stem cell transplantation technology,anti-aging treatment or treatment of degenerative diseases through the input of stem cells has become a research hotspot.Human umbilical cord mesenchymal stem cells(HUCMSCs)are unique precursor cells which are derived from Wharton’s jelly and the perivascular tissue of umbilical cord.They have been identified to be self-renewal and multi-differentiation potential.Currently,a large number of scientific studies have shown that HUCMSCs can achieve anti-aging effects by regenerating and repairing senescent cells,tissues and organs.This article reviews the research advances in biological characteristics,tissue regeneration and repair mechanisms,and anti-aging treatment mechanisms of HUCMSCs in detail.Besides,the current status of preclinical research on HUCMSCs is summarized,suggesting that HUCMSCs is a type of stem cell therapy with good potential and value.