JAK/STAT信号通路在炎症性肠病发病机制中的研究进展

Advances of JAK/STAT signaling pathway in the pathogenesis of inflammatory bowel disease

Janus激酶/信号传导与转录激活子(Janus kinase/signal transduction and activator of transcription,JAK/STAT)信号通路是众多细胞因子信号传导的共同途径,不同程度地参与细胞增殖、分化、凋亡及炎症等过程,进而促进各种疾病的发生、发展,包括炎症性肠病(inflammatory bowel disease,IBD)。IBD是一种肠道慢性非特异性炎症疾病,常反复发作且病因不明。我们通过探讨JAK/STAT信号传导结构及其促成IBD发病的相关机制,并就JAK抑制剂在JAK/STAT信号通路在IBD现在和未来的治疗方法中的应用作一概述。

The Janus kinase/signal transduction and activator of transcription(JAK/STAT)signaling pathway is a common pathway for many cytokine signaling pathways,and it is involved in cell proliferation,differentiation,apoptosis,and inflammation to varying degrees.Processes such as apoptosis and inflammation promote the development and progression of various diseases,including inflammatory bowel diseases(IBD).IBD is a chronic,non-specific inflammatory disease of the intestine that is often recurrent and the cause is unknown.In this review,we will explore the mechanisms by which JAK/STAT signaling its structure and its mechanisms contribute to the pathogenesis of IBD,and the application of JAK inhibitors in the JAK/STAT signaling pathway in current and future therapeutic approaches of IBD.