羊栖菜多糖抗肿瘤及其作用机制研究进展

Progress in research on the antitumor activities of Sargassum fusiforme polysaccharides and their underlying mechanisms

羊栖菜(Sargassum fusiforme)多糖在多种肿瘤细胞系中表现出良好的抗癌活性,具有针对肿瘤细胞的选择活性和较小的毒副作用,可以作为现有肿瘤化疗药物的替代品进行开发。羊栖菜多糖主要通过诱导细胞凋亡作用于肿瘤细胞,其通过细胞周期停滞,增强机体免疫功能,改变细胞膜钙通道与流动性,破坏线粒体膜和产生一氧化氮来杀死癌细胞并防止转移。本文就国内外发表的羊栖菜多糖抗肿瘤功能及作用机制进行系统的归纳和总结,旨在为羊栖菜多糖抗肿瘤药物的深入研究、开发提供理论依据。

A polysaccharide isolated from Sargassum fusiforme is a succedaneum being developed for chemotherapeutic medicine.It displays antitumor activity in various tumor cell lines,exhibits good anticancer activity in several cancer cell lines,and possesses selective activity against tumor cells with minimal toxic side effects.Polysaccharides isolated from S.fusiforme have been reported to act on malignant cells mainly via induction of apoptosis.They kill cancer cells,prevent metastasis via cell cycle arrest,enhance immunity,effect changes in calcium channels,alter cell membrane fluidity,disrupt mitochondrial membrane,and produce nitric oxide.The present study aimed to review previous research conducted on the antitumor activities of S.fusiforme polysaccharides and the mechanisms underlying these antitumor activities to provide a theoretical and evidential basis for in-depth exploration and understanding of these polysaccharides.